{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T08:48:54Z","timestamp":1785746934981,"version":"3.56.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,8,18]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The development of pathological cardiac hypertrophy involves the coordination of a series of transcription activators and repressors, while their interplay to trigger pathological gene reprogramming remains unclear. NULP1 (nuclear localized protein 1) is a member of the basic helix\u2010loop\u2010helix family of transcription factors and its biological functions in pathological cardiac hypertrophy are barely understood.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Immunoblot and immunostaining analyses showed that NULP1 expression was consistently reduced in the failing hearts of patients and hypertrophic mouse hearts and rat cardiomyocytes.\n              <jats:italic>Nulp1<\/jats:italic>\n              knockout exacerbates aortic banding\u2010induced cardiac hypertrophy pathology, which was significantly blunted by transgenic overexpression of\n              <jats:italic>Nulp1<\/jats:italic>\n              . Signal pathway screening revealed the nuclear factor of activated T cells (NFAT) pathway to be dramatically suppressed by NULP1. Coimmunoprecipitation showed that NULP1 directly interacted with the topologically associating domain of NFAT3 via its C\u2010terminal region, which was sufficient to suppress NFAT3 transcriptional activity. Inactivation of the NFAT pathway by VIVIT peptides in vivo rescued the aggravated pathogenesis of cardiac hypertrophy resulting from\n              <jats:italic>Nulp1<\/jats:italic>\n              deficiency.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">NULP1 is an endogenous suppressor of NFAT3 signaling under hypertrophic stress and thus negatively regulates the pathogenesis of cardiac hypertrophy. Targeting overactivated NFAT by NULP1 may be a novel therapeutic strategy for the treatment of pathological cardiac hypertrophy and heart failure.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.016419","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T08:50:44Z","timestamp":1596531044000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["NULP1 Alleviates Cardiac Hypertrophy by Suppressing NFAT3 Transcriptional Activity"],"prefix":"10.1161","volume":"9","author":[{"given":"Xin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiology College of Life Sciences Zhongnan Hospital of Wuhan UniversityWuhan University Wuhan China"},{"name":"Institute of Model Animal Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Lei","sequence":"additional","affiliation":[{"name":"Institute of Model Animal Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Ming","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Wuhan University Wuhan China"},{"name":"Institute of Model Animal Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke\u2010Qiong","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Cardiology College of Life Sciences Zhongnan Hospital of Wuhan UniversityWuhan University Wuhan China"},{"name":"Institute of Model Animal Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3401-2427","authenticated-orcid":false,"given":"Yan\u2010Xiao","family":"Ji","sequence":"additional","affiliation":[{"name":"Institute of Model Animal Wuhan University Wuhan China"},{"name":"Medical Science Research Center Zhongnan Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8414-9958","authenticated-orcid":false,"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Model Animal Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9821-0297","authenticated-orcid":false,"given":"Hongliang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Wuhan University Wuhan China"},{"name":"Institute of Model Animal Wuhan University Wuhan China"},{"name":"Medical Science Research Center Zhongnan Hospital of Wuhan University Wuhan China"},{"name":"Department of Cardiology Renmin Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Dong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology College of Life Sciences Zhongnan Hospital of Wuhan UniversityWuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7950-3465","authenticated-orcid":false,"given":"Zhibing","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Cardiology College of Life Sciences Zhongnan Hospital of Wuhan UniversityWuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9705-8644","authenticated-orcid":false,"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology College of Life Sciences Zhongnan Hospital of Wuhan UniversityWuhan University Wuhan China"},{"name":"Institute of Model Animal Wuhan University Wuhan China"},{"name":"Medical Science Research Center Zhongnan Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra072139"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2016.06.001"},{"key":"e_1_3_1_4_2","first-page":"611","article-title":"Signalling pathways in cardiac myocyte hypertrophy","volume":"33","author":"Sugden PH","year":"2001","unstructured":"Sugden PH. 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