{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T23:45:11Z","timestamp":1785541511585,"version":"3.56.0"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"24","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,12,15]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Hypergravity may promote human hemostasis thereby increasing thrombotic risk. Future touristic suborbital spaceflight will expose older individuals with chronic medical conditions, who are at much higher thromboembolic risk compared with professional astronauts, to hypergravity. Therefore, we tested the impact of hypergravity on hemostasis in healthy volunteers undergoing centrifugation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We studied 20 healthy seated men before and after 15\u00a0minutes under 3\u00a0Gz hypergravity on a long\u2010arm centrifuge. We obtained blood samples for hemostasis testing before, immediately after, and 30\u00a0minutes after centrifugation. Tests included viscoelastic thromboelastometry, platelet impedance aggregometry, endothelial activation markers, blood rheology testing, microparticle analyses, and clotting factor analysis. Exposure to hypergravity reduced plasma volume by 12.5% (\n              <jats:italic>P<\/jats:italic>\n              =0.002) and increased the red blood cell aggregation index (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05). With hypergravity, thrombelastographic clotting time of native blood shortened from 719\u00b1117\u00a0seconds to 628\u00b189\u00a0seconds (\n              <jats:italic>P<\/jats:italic>\n              =0.038) and platetet reactivity increased (\n              <jats:italic>P<\/jats:italic>\n              =0.045). Hypergravity shortened partial thromboplastin time from 28 (26\u201329) seconds to 25 (24\u201328) seconds (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and increased the activity of coagulation factors (eg, factor VIII 117 [93\u2013134] versus 151 [133\u2013175] %,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Tissue factor concentration was 188\u00b195\u00a0pg\/mL before and 298\u00b1136\u00a0pg\/mL after hypergravity exposure (\n              <jats:italic>P<\/jats:italic>\n              =0.023). Antithrombin (\n              <jats:italic>P<\/jats:italic>\n              =0.005), thrombin\u2010antithrombin complex (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), plasmin\u2010alpha2\u2010antiplasmin complex (0.002), tissue\u2010plasminogen activatior (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), and plasminogen activator inhibitor\u20101 (\n              <jats:italic>P<\/jats:italic>\n              =0.002) increased with centrifugation. Statistical adjustment for plasma volume attenuated changes in coagulation.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Hypergravity triggers low\u2010level hemostasis activation through endothelial cell activation, increased viscoelasticity, and augmented platelet reactivity, albeit partly counteracted through endogenous coagulation inhibitors release. Hemoconcentration may contribute to the response.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.016479","type":"journal-article","created":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T12:01:02Z","timestamp":1607342462000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Simulated Hypergravity Activates Hemostasis in Healthy Volunteers"],"prefix":"10.1161","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9927-4180","authenticated-orcid":false,"given":"Ulrich","family":"Limper","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine Merheim Medical Center Hospitals of Cologne University of Witten\/Herdecke Cologne Germany"},{"name":"German Aerospace Center (DLR)Institute of Aerospace Medicine Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Ahnert","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Traumatology and Sports Medicine Merheim Medical Center Hospitals of Cologne University of Witten\/Herdecke Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Maegele","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Traumatology and Sports Medicine Merheim Medical Center Hospitals of Cologne University of Witten\/Herdecke Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Froehlich","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Traumatology and Sports Medicine Merheim Medical Center Hospitals of Cologne University of Witten\/Herdecke Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijke","family":"Grau","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Sports Medicine German Sport University Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Gauger","sequence":"additional","affiliation":[{"name":"German Aerospace Center (DLR)Institute of Aerospace Medicine Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Bauerfeind","sequence":"additional","affiliation":[{"name":"Department of Haematology and Transfusion Medicine (DTM) Merheim Medical Center Hospitals of Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7315-9528","authenticated-orcid":false,"given":"Klaus","family":"G\u00f6rlinger","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine University Hospital Essen Essen Germany"},{"name":"Medical Director Tem Innovations Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"P\u00f6tzsch","sequence":"additional","affiliation":[{"name":"Institute of Experimental Haematology and Transfusion Medicine University Hospital Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4518-0706","authenticated-orcid":false,"given":"Jens","family":"Jordan","sequence":"additional","affiliation":[{"name":"German Aerospace Center (DLR)Institute of Aerospace Medicine Cologne Germany"},{"name":"Chair of Aerospace Medicine Medical Faculty University of Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.112003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12959-017-0139-z"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042221"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12383"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00012"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lssr.2017.01.004"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/434803"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01209.2009"},{"key":"e_1_3_2_10_2","first-page":"1106","article-title":"Myocardial infarction occurring at the conclusion of centrifuge training in a 37\u2010year\u2010old aviator","volume":"63","author":"Cayce WR","year":"1992","unstructured":"Cayce WR, Zerull RG. 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