{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:52:00Z","timestamp":1790639520174,"version":"4.1.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,7,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In most post\u2013cardiac arrest patients, the autoregulation mechanism of cerebral blood flow (\n              <jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content>\n              ) is dysregulated. We examined whether recovery of\n              <jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content>\n              by adjusting mean arterial pressure mitigates post\u2013cardiac arrest neuronal damage.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Wistar rats that underwent 8\u2010minute asphyxia\u2010induced cardiac arrest and resuscitation were computer\u2010randomized to norepinephrine or control groups. The\n              <jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content>\n              was measured at the dorsal hippocampal\n              <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\n              1 region of the left hemisphere. In the norepinephrine group, the mean arterial pressure was adjusted to recover\n              <jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content>\n              to 80% to 100% of baseline. Twenty\u2010four hours following resuscitation, neurological outcomes were assessed, and brain tissues and blood samples were harvested for neuronal apoptosis and injury assessment. Thirty resuscitated rats were randomized into 2 groups, each containing 12 rats that completed the experiments. Norepinephrine infusion effectively prevented posthyperemia hypoperfusion and recovered\n              <jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content>\n              to pre\u2010arrest baseline levels; a moderate positive linear correlation between mean arterial pressure and\n              <jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content>\n              during this period was also observed (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). There were no significant between\u2010group differences in neurological recovery. In the norepinephrine group compared with the control group, upregulated cleaved caspase\u20103 protein expression in brain tissue determined by Western blot was reduced (\n              <jats:italic>P<\/jats:italic>\n              =0.02) and the densities of apoptotic cells in hippocampal\n              <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\n              1 and\n              <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\n              3 regions determined by terminal deoxynucleotidyl transferase\u2010mediated dUTP biotin nick\u2010end labeling were decreased (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). No significant differences in serum neuron\u2010specific enolase or S100\u03b2 levels were detected between the 2 groups.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content>\n              recovery demonstrated neuroprotective effects by reducing activation of cerebral apoptosis and number of apoptotic neurons. However, these effects did not significantly improve clinical neurological function, necessitating further investigation.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.016513","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T09:36:22Z","timestamp":1592386582000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Cerebral Blood Flow\u2013Guided Manipulation of Arterial Blood Pressure Attenuates Hippocampal Apoptosis After Asphyxia\u2010Induced Cardiac Arrest in Rats"],"prefix":"10.1161","volume":"9","author":[{"given":"Chih\u2010Hung","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine National Taiwan University Hospital Taipei Taiwan"},{"name":"Department of Emergency Medicine College of Medicine National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Tien","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine National Taiwan University Hospital Taipei Taiwan"},{"name":"Department of Emergency Medicine College of Medicine National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien\u2010Hua","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine National Taiwan University Hospital Taipei Taiwan"},{"name":"Department of Emergency Medicine College of Medicine National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Shan","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine National Taiwan University Hospital Taipei Taiwan"},{"name":"Department of Emergency Medicine College of Medicine National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shing\u2010Hwa","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Toxicology College of Medicine National Taiwan University Taipei Taiwan"},{"name":"Department of Medical Research China Medical University Hospital China Medical University Taichung Taiwan"},{"name":"Department of Pediatrics National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2098-5922","authenticated-orcid":false,"given":"Wen\u2010Jone","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine National Taiwan University Hospital Taipei Taiwan"},{"name":"Department of Emergency Medicine College of Medicine National Taiwan University Taipei Taiwan"},{"name":"Division of Cardiology Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2010.08.006"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000485"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2008.09.017"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-004-2425-z"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2015.07.018"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000262"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2017.00174"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.1.128"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.27.1.105"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.21.8.1178"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2012.10.023"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166324"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00763.2011"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31819cee38"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000131940.19833.85"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0000000000000194"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2014.03.314"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)90833-2"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410110509"},{"key":"e_1_3_2_21_2","first-page":"437","article-title":"Cerebral ischemia. II. The no\u2010reflow phenomenon","volume":"52","author":"Ames A","year":"1968","unstructured":"Ames A III, Wright RL, Kowada M, Thurston JM, Majno G. Cerebral ischemia. II. The no\u2010reflow phenomenon. Am J Pathol. 1968;52:437\u2013453.","journal-title":"Am J Pathol"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9572(96)01029-5"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2015.03.001"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9572(00)00268-9"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.8.1569"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-018-5446-8"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.53.4.720"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003474"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.05.131"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2015.10.020"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(86)80175-5"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1999.79.4.1431"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(98)00024-0"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2016.10.013"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-015-0214-x"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2013.08.014"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2008.12.012"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.120.016513","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:37:29Z","timestamp":1715600249000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.120.016513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,7]]},"references-count":36,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2020,7,7]]}},"alternative-id":["10.1161\/JAHA.120.016513"],"URL":"https:\/\/doi.org\/10.1161\/jaha.120.016513","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,7]]},"assertion":[{"value":"2020-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e016513"}}