{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:27:38Z","timestamp":1790162858209,"version":"4.1.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,10,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">There are limited data on health status instruments in patients with peripheral artery disease and cardiovascular and limb events. We evaluated the relationship between health status changes and cardiovascular and limb events.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In an analysis of the EUCLID (Examining Use of Ticagrelor in Symptomatic Peripheral Artery Disease) trial, we examined the characteristics of 13\u00a0801 patients by tertile of health status instrument scores collected in the trial (EuroQol 5\u2010Dimensions [EQ\u20105D], EQ visual analog scale [VAS], and peripheral artery questionnaire). We assessed the association between the baseline health status measurements and major adverse cardiovascular events, major adverse limb events, and lower\u2010extremity revascularization procedures during trial follow\u2010up and the association between 12\u2010month health status change scores and subsequent end points during follow\u2010up. There were 13\u00a0217 (95%) patients with EQ\u20105D scores, 13\u00a0533 (98%) with VAS scores, and 4431 (32%) with peripheral artery questionnaire scores. Patients in the lowest baseline EQ\u20105D tertile (0 to &lt;0.69) were more likely to be female with severe claudication compared with the highest tertile (0.79\u20131.0;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01). Patients in the lowest VAS (0\u201360) and peripheral artery questionnaire (0\u201349) tertiles had lower ankle\u2013brachial indices compared with the highest tertiles (80\u2013100 and 76\u2013108, respectively;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01). There was a significant association between baseline EQ\u20105D, VAS, and peripheral artery questionnaire scores and adjusted major adverse cardiovascular events, major adverse limb events, and lower\u2010extremity revascularization (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05). Improved EQ\u20105D and VAS scores over 12\u00a0months were associated with reduced risk of subsequent major adverse cardiovascular events or lower\u2010extremity revascularization (all\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Although health status instruments are rarely used in clinical practice, these measures are associated with outcomes, including major adverse cardiovascular events, major adverse limb events, and lower\u2010extremity revascularization. Further research is needed to determine the relationship between changes in these instruments, revascularization, and outcomes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.016573","type":"journal-article","created":{"date-parts":[[2020,9,13]],"date-time":"2020-09-13T09:14:36Z","timestamp":1599988476000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Association of Health Status Scores With Cardiovascular and Limb Outcomes in Patients With Symptomatic Peripheral Artery Disease: Insights From the EUCLID (Examining Use of Ticagrelor in Symptomatic Peripheral Artery Disease) Trial"],"prefix":"10.1161","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9841-2393","authenticated-orcid":false,"given":"Jennifer A.","family":"Rymer","sequence":"first","affiliation":[{"name":"Division of Cardiology Duke University Medical Center Durham NC"},{"name":"Duke Clinical Research Institute Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hillary","family":"Mulder","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6104-6254","authenticated-orcid":false,"given":"Kim G.","family":"Smolderen","sequence":"additional","affiliation":[{"name":"Vascular Medicine Outcomes Program Yale University New Haven CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7571-7557","authenticated-orcid":false,"given":"William R.","family":"Hiatt","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Colorado Prevention Center University of Colorado School of Medicine Aurora CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9119-192X","authenticated-orcid":false,"given":"Michael S.","family":"Conte","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery University of California San Francisco San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8216-4647","authenticated-orcid":false,"given":"Jeffrey S.","family":"Berger","sequence":"additional","affiliation":[{"name":"Division of Cardiology NYU Langone Health New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Norgren","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Orebro University Orebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth W.","family":"Mahaffey","sequence":"additional","affiliation":[{"name":"Stanford Center for Clinical Research Stanford University School of Medicine Stanford CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Baumgartner","sequence":"additional","affiliation":[{"name":"Swiss Cardiovascular Center Inselspital Bern University Hospital University of Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Gerry","family":"Fowkes","sequence":"additional","affiliation":[{"name":"Usher Institute of Population Health Sciences and Informatics University of Edinburgh United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian G.","family":"Katona","sequence":"additional","affiliation":[{"name":"AstraZeneca Gaithersburg MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3732-4765","authenticated-orcid":false,"given":"Frank","family":"Rockhold","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Durham NC"},{"name":"Department of Biostatistics and Bioinformatics Duke University Medical Center Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Schuyler","family":"Jones","sequence":"additional","affiliation":[{"name":"Division of Cardiology Duke University Medical Center Durham NC"},{"name":"Duke Clinical Research Institute Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manesh R.","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Cardiology Duke University Medical Center Durham NC"},{"name":"Duke Clinical Research Institute Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2003.08.001"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(02)00131-3"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-016-0563-y"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X12466708"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.2217\/cer-2017-0029"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.075770"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvn.2017.09.003"},{"key":"e_1_3_1_9_2","first-page":"204","article-title":"Aerobic arm exercise to improve outcomes for patients with severe claudication and ischemic rest pain","author":"Treat\u2010Jacobson D","year":"2012","unstructured":"Treat\u2010Jacobson D, Bronas UG, Krause BJ, Robinson C, Santilli S, Leon A. 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