{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:43:28Z","timestamp":1789206208546,"version":"build-2803163510"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,8,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Few studies have investigated optimal revascularization strategies in non\u2013ST\u2010segment\u2013elevation myocardial infarction with multivessel disease. We investigated 3\u2010year clinical outcomes according to revascularization strategy in patients with non\u2013ST\u2010segment\u2013elevation myocardial infarction and multivessel disease.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This retrospective, observational, multicenter study included patients with non\u2013ST\u2010segment\u2013elevation myocardial infarction and multivessel disease without cardiogenic shock. Data were analyzed at 3\u00a0years according to the percutaneous coronary intervention strategy: culprit\u2010only revascularization (COR), 1\u2010stage multivessel revascularization (MVR), and multistage MVR. The primary outcome was major adverse cardiac events (MACE: a composite of all\u2010cause death, nonfatal spontaneous myocardial infarction, or any repeat revascularization). The COR group had a higher risk of MACE than those involving other strategies (COR versus 1\u2010stage MVR; hazard ratio, 0.65; 95% CI, 0.54\u20130.77;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001; and COR versus multistage MVR; hazard ratio, 0.74; 95% CI, 0.57\u20130.97;\n              <jats:italic>P<\/jats:italic>\n              =0.027). There was no significant difference in the incidence of MACE between 1\u2010stage and multistage MVR (hazard ratio, 1.14; 95% CI, 0.86\u20131.51;\n              <jats:italic>P<\/jats:italic>\n              =0.355). The results were consistent after multivariate regression, propensity score matching, inverse probability weighting, and Bayesian proportional hazards modeling. In subgroup analyses stratified by the Global Registry of Acute Coronary Events score, 1\u2010stage MVR lowered the risk of MACE compared with multistage MVR in low\u2010to\u2010intermediate risk patients but not in patients at high risk.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">MVR reduced 3\u2010year MACE in patients with non\u2013ST\u2010segment\u2013elevation myocardial infarction and multivessel disease compared with COR. However, 1\u2010stage MVR was not superior to multistage MVR for reducing MACE except in low\u2010to\u2010intermediate risk patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.016575","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T09:12:52Z","timestamp":1596186772000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["Optimal Revascularization Strategy in Non\u2013ST\u2010Segment\u2013Elevation Myocardial Infarction With Multivessel Coronary Artery Disease: Culprit\u2010Only Versus One\u2010Stage Versus Multistage Revascularization"],"prefix":"10.1161","volume":"9","author":[{"given":"Min Chul","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Cardiology Chonnam National University HospitalChonnam National University Medical School Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Yong","family":"Hyun","sequence":"additional","affiliation":[{"name":"Department of Cardiology Chonnam National University HospitalChonnam National University Medical School Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2022-9366","authenticated-orcid":false,"given":"Youngkeun","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Cardiology Chonnam National University HospitalChonnam National University Medical School Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1484-4645","authenticated-orcid":false,"given":"SungA","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Cardiology Chonnam National University HospitalChonnam National University Medical School Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Young","family":"Hyun","sequence":"additional","affiliation":[{"name":"Department of Cardiology Chonnam National University HospitalChonnam National University Medical School Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0377-6352","authenticated-orcid":false,"given":"Kyung Hoon","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Cardiology Chonnam National University HospitalChonnam National University Medical School Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doo Sun","family":"Sim","sequence":"additional","affiliation":[{"name":"Department of Cardiology Chonnam National University HospitalChonnam National University Medical School Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Joon","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Cardiology Chonnam National University HospitalChonnam National University Medical School Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3186-0770","authenticated-orcid":false,"given":"Ju Han","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Cardiology Chonnam National University HospitalChonnam National University Medical School Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung Ho","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Cardiology Chonnam National University HospitalChonnam National University Medical School Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0847-5329","authenticated-orcid":false,"given":"Hyo\u2010Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Cardiology Seoul National University Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeon Cheol","family":"Gwon","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sungkyunkwan University Samsung Medical Center Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Whan","family":"Seong","sequence":"additional","affiliation":[{"name":"Department of Cardiology Chungnam National University Hospital Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung\u2010Kook","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Chungbuk National University Hospital Cheongju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shung Chull","family":"Chae","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kyungpook National University Hospital Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3895-1915","authenticated-orcid":false,"given":"Seung Ho","family":"Hur","sequence":"additional","affiliation":[{"name":"Department of Cardiology Keimyung University Dongsan Medical Center Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Soo","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Cardiology Pusan National University Hospital Busan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7545-0143","authenticated-orcid":false,"given":"Seok Kyu","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Cardiology Wonkwang University Hospital Iksan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.108.825323"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.03.051"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1305520"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.12.038"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60648-1"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1701067"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1907775"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx393"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.10.082"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.10.054"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2010.08.044"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.07.089"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.112.974485"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy394"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-16-0061"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.08.1038"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv320"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2711"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38985.646481.55"}],"container-title":["Journal 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