{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T07:56:31Z","timestamp":1759564591617,"version":"3.41.2"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"24","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,12,15]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Despite the benefits of targeted temperature management (TTM) for out\u2010of\u2010hospital cardiac arrest), implementation within the United States remains low. The objective of this study was to evaluate the prevalence and factors associated with TTM use in a large, urban\u2010suburban regional system of care.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">This was a retrospective analysis from the Los Angeles County regional cardiac system of care serving a population of &gt;10\u00a0million residents. All adult patients aged \u226518\u00a0years with non\u2010traumatic out\u2010of\u2010hospital cardiac arrest transported to a cardiac arrest center from April 2011 to August 2017 were included. Patients awake and alert in the emergency department and patients who died in the emergency department before consideration for TTM were excluded. The primary outcome measure was prevalence of TTM use. The secondary analysis were annual trends in TTM use over the study period and factors associated with TTM use. The study population included 8072 patients; 4154 patients (51.5%) received TTM and 3767 patients (46.7%) did not receive TTM. Median age was 67\u00a0years, 4780 patients (59.2%) were men, 4645 patients (57.5%) were non\u2010White, and the most common arrest location was personal residence in 4841 patients (60.0%). In the adjusted analysis, younger age, male sex, an initial shockable rhythm, witnessed arrest, and receiving coronary angiography were associated with receiving TTM.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Within this regional system of care, use of TTM was higher than previously reported in the literature at just over 50%. Use of integrated systems of care may be a novel method to increase TTM use within the United States.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.016652","type":"journal-article","created":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T13:12:41Z","timestamp":1606914761000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Implementation of Targeted Temperature Management After Out\u2010of\u2010Hospital Cardiac Arrest: Observations From the Los Angeles County Regional System"],"prefix":"10.1161","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8311-4326","authenticated-orcid":false,"given":"Melody","family":"Hermel","sequence":"first","affiliation":[{"name":"Division of Cardiology University of Southern California Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8356-0772","authenticated-orcid":false,"given":"Nichole","family":"Bosson","sequence":"additional","affiliation":[{"name":"Los Angeles County Emergency Medical Service Agency Santa Fe Springs CA"},{"name":"Department of Emergency Medicine Harbor UCLA Medical Center Torrance CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Stanford University Stanford CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"French","sequence":"additional","affiliation":[{"name":"Division of Cardiology Harbor UCLA Medical Center Torrance CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James T.","family":"Niemann","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Harbor UCLA Medical Center Torrance CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gene","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Southern California Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph L.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Division of Cardiology Harbor UCLA Medical Center Torrance CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9209-9807","authenticated-orcid":false,"given":"David M.","family":"Shavelle","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Southern California Los Angeles 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