{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T15:44:50Z","timestamp":1781711090960,"version":"3.54.5"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,11,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">In a recent multicenter study of perinatal outcome in fetuses with Ebstein anomaly or tricuspid valve dysplasia, we found that one third of live\u2010born patients died before hospital discharge. We sought to further describe postnatal management strategies and to define risk factors for neonatal mortality and circulatory outcome at discharge.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This 23\u2010center, retrospective study from 2005 to 2011 included 243 fetuses with Ebstein anomaly or tricuspid valve dysplasia. Among live\u2010born patients, clinical and echocardiographic factors were evaluated for association with neonatal mortality and palliated versus biventricular circulation at discharge. Of 176 live\u2010born patients, 7 received comfort care, 11 died &lt;24\u00a0hours after birth, and 4 had insufficient data. Among 154 remaining patients, 38 (25%) did not survive to discharge. Nearly half (46%) underwent intervention. Mortality differed by procedure; no deaths occurred in patients who underwent right ventricular exclusion. At discharge, 56% of the cohort had a biventricular circulation (13% following intervention) and 19% were palliated. Lower tricuspid regurgitation jet velocity (odds ratio [OR], 2.3 [1.1\u20135.0], 95% CI, per m\/s;\n              <jats:italic>P<\/jats:italic>\n              =0.025) and lack of antegrade flow across the pulmonary valve (OR, 4.5 [1.3\u201314.2];\n              <jats:italic>P<\/jats:italic>\n              =0.015) were associated with neonatal mortality by multivariable logistic regression. These variables, along with smaller pulmonary valve dimension, were also associated with a palliated outcome.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Among neonates with Ebstein anomaly or tricuspid valve dysplasia diagnosed in utero, a variety of management strategies were used across centers, with poor outcomes overall. High\u2010risk patients with low tricuspid regurgitation jet velocity and no antegrade pulmonary blood flow should be considered for right ventricular exclusion to optimize their chance of survival.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.016684","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T09:00:55Z","timestamp":1603184455000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":49,"title":["Risk Factors for Mortality and Circulatory Outcome Among Neonates Prenatally Diagnosed With Ebstein Anomaly or Tricuspid Valve Dysplasia: A Multicenter Study"],"prefix":"10.1161","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1221-081X","authenticated-orcid":false,"given":"Lindsay R.","family":"Freud","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Pediatrics NewYork\u2010Presbyterian Morgan Stanley Children\u2019s Hospital Columbia 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Cardiology Department of Pediatrics Texas Children\u2019s Hospital Baylor College of Medicine Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay D.","family":"Pruetz","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Pediatrics Children\u2019s Hospital Los Angeles University of Southern California Keck School of Medicine Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"van der Velde","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Pediatrics University of Michigan Congenital Heart Center C.S. Mott Children\u2019s Hospital University of Michigan Medical School Ann Arbor MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Kovalchin","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Pediatrics Nationwide Children\u2019s Hospital Ohio State University College of Medicine Columbus OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M.","family":"Ikemba","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Pediatrics Children\u2019s Medical Center University of Texas Southwestern Medical School Dallas TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret M.","family":"Vernon","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Pediatrics Seattle Children\u2019s Hospital University of Washington School of Medicine Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrus","family":"Samai","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Pediatrics Children\u2019s Healthcare of Atlanta Emory University School of Medicine Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary M.","family":"Satou","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Pediatrics Mattel Children\u2019s Hospital University of California\u2010Los Angeles David Geffen School of Medicine Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina L.","family":"Gotteiner","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Pediatrics Ann &amp; Robert H. 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