{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:35:20Z","timestamp":1791920120631,"version":"4.3.4"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,8,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Extracellular superoxide dismutase (Ec\u2010SOD) is a major scavenger of reactive oxygen species. However, its relationships with abnormal left ventricular (LV) geometry patterns and heart failure (HF) are still unknown in patients with cardiovascular disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      A cross\u2010sectional study was carried out to evaluate the association of serum Ec\u2010SOD activity with LV geometry, as well as HF in 1047 patients with cardiovascular disease. All participants underwent standard echocardiography examination and measurement of serum Ec\u2010SOD activity. Overall, we found a significantly decreased trend of serum Ec\u2010SOD activity from subjects with normal geometry (147.96\u00b115.94\u00a0U\/mL), subjects with abnormal LV geometry without HF (140.19\u00b120.12\u00a0U\/mL), and subjects with abnormal LV geometry and overt HF (129.32\u00b117.92\u00a0U\/mL) after adjustment for potential confounders (\n                      <jats:italic>P<\/jats:italic>\n                      for trend &lt;0.001). The downward trends remained significant in the concentric hypertrophy and eccentric hypertrophy groups after stratification by different LV geometry patterns. Multinomial logistic regression analysis showed that each 10\u00a0U\/mL increase in serum Ec\u2010SOD activity was associated with a 16.5% decrease in the odds of concentric remodeling without HF (odds ratio [OR], 0.835; 95% CI, 0.736\u20130.948), a 40.4% decrease in the odds of concentric hypertrophy with HF (OR, 0.596; 95% CI, 0.486\u20130.730), a 16.1% decrease in the odds of eccentric hypertrophy without HF (OR, 0.839; 95% CI, 0.729\u20130.965) and a 34.0% decrease in the odds of eccentric hypertrophy with HF (OR, 0.660; 95% CI, 0.565\u20130.772).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Serum Ec\u2010SOD activity was independently associated with abnormal LV geometry patterns with and without overt HF. Our results indicate that Ec\u2010SOD might be a potential link between LV structure remodeling and the development of subsequent HF in patients with cardiovascular disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier NCT03351907.\n                    <\/jats:p>\n                  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Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangxin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sun Yat\u2010sen Memorial HospitalSun Yat\u2010sen University Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5330-6466","authenticated-orcid":false,"given":"Min","family":"Xia","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Food, Nutrition and Health Guangzhou Guangdong Province China"},{"name":"Department of Nutrition School of Public Health Sun Yat\u2010sen University (Northern Campus) Guangzhou Guangdong Province 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