{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T05:05:30Z","timestamp":1761541530921,"version":"3.41.2"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,8,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Intracerebral hemorrhage (ICH) risk is higher in elderly patients with atrial fibrillation on antithrombotic therapy as well as those with cerebral amyloid angiopathy (CAA). We investigated if mortality among patients with atrial fibrillation on antithrombotic therapy presenting with non\u2010traumatic ICH was influenced by underlying CAA.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We used the Rochester Epidemiology Project to identify 6045 patients with atrial fibrillation aged &gt;55 years on anticoagulation or antiplatelet therapy from 1995 to 2016. Seventy\u2010four patients in this cohort presented with non\u2010traumatic ICH. Medical records including imaging data were reviewed to identify those with CAA and record baseline variables and outcomes of interest; 38 of our 74 patients (51.4%) (mean age 81.5\u00a0years) met Modified Boston Criteria for possible or probable CAA. Twenty\u2010six of 74 patients (35%) died during the first 30\u00a0days while 56 of the 74 (76%) patients died by 10\u00a0years follow\u2010up after index ICH. Overall mortality was not significantly different between the CAA and non\u2010CAA groups at any point of time during follow\u2010up (\n              <jats:italic>P<\/jats:italic>\n              =0.89) even amongst patients restarted on anticoagulation +\/\u2212 antiplatelet (n=19) (\n              <jats:italic>P<\/jats:italic>\n              =0.46) or those patients restarted only on antiplatelet therapy (n=22) (\n              <jats:italic>P<\/jats:italic>\n              =0.66). Three of the 41 patients who restarted on antithrombotic therapy had a recurrent ICH; these 3 patients met criteria for possible or probable CAA.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Although more than half of our patients with atrial fibrillation on antithrombotic therapy and non\u2010traumatic ICH met Modified Boston Criteria for CAA, CAA did not significantly influence the high mortality seen in this cohort.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.016893","type":"journal-article","created":{"date-parts":[[2020,7,25]],"date-time":"2020-07-25T09:16:45Z","timestamp":1595668605000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["High Mortality Rates Among Patients With Non\u2010Traumatic Intracerebral Hemorrhage and Atrial Fibrillation on Antithrombotic Therapy Are Independent of the Presence of Cerebral Amyloid Angiopathy: Insights From a Population\u2010Based Study"],"prefix":"10.1161","volume":"9","author":[{"given":"Shiva P.","family":"Ponamgi","sequence":"first","affiliation":[{"name":"Division of Hospital Internal Medicine Mayo Clinic Health System Austin MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Ward","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Mayo Clinic Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher V.","family":"DeSimone","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases Mayo Clinic Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8460-2193","authenticated-orcid":false,"given":"Stephen","family":"English","sequence":"additional","affiliation":[{"name":"Department of Neurology Emory University Atlanta GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David O.","family":"Hodge","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Jacksonville FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua P.","family":"Slusser","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2770-0691","authenticated-orcid":false,"given":"Jonathan","family":"Graff\u2010Radford","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro A.","family":"Rabinstein","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9835-5536","authenticated-orcid":false,"given":"Samuel J.","family":"Asirvatham","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases Mayo Clinic Rochester MN"},{"name":"Department of Pediatrics and Adolescent Medicine Mayo Clinic Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0037-0373","authenticated-orcid":false,"suffix":"Jr.","given":"David","family":"Holmes","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases Mayo Clinic Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"doi-asserted-by":"publisher","key":"e_1_3_1_2_2","DOI":"10.1161\/01.STR.22.8.983"},{"doi-asserted-by":"publisher","key":"e_1_3_1_3_2","DOI":"10.1161\/STROKEAHA.113.002329"},{"doi-asserted-by":"publisher","key":"e_1_3_1_4_2","DOI":"10.1161\/CIRCULATIONAHA.117.031658"},{"doi-asserted-by":"publisher","key":"e_1_3_1_5_2","DOI":"10.1253\/circj.CJ-13-0465"},{"doi-asserted-by":"publisher","key":"e_1_3_1_6_2","DOI":"10.1186\/s12875-016-0574-0"},{"doi-asserted-by":"publisher","key":"e_1_3_1_7_2","DOI":"10.1093\/ageing\/afr097"},{"key":"e_1_3_1_8_2","first-page":"807","article-title":"Compliance and adherence to oral anticoagulation therapy in elderly patients with atrial fibrillation in the era of direct oral anticoagulants","author":"Garkina SV","year":"2016","unstructured":"Garkina SV, Vavilova TV, Lebedev DS, Mikhaylov EN. 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