{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:21:18Z","timestamp":1792016478531,"version":"4.4.0"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>BACKGROUND<\/jats:title>\n            <jats:p xml:lang=\"en\">Coronavirus disease 2019 (COVID\u201019) is the cause of a pandemic disease, with severe acute respiratory syndrome by binding target epithelial lung cells through angiotensin\u2010converting enzyme 2 in humans. Thus, patients with hypertension with COVID\u201019 could have worse prognosis. Indeed, angiotensin\u2010converting enzyme inhibitors and\/or angiotensin receptor blockers may interfere with angiotensin\u2010converting enzyme 2 expression\/activity. Thus, patients with hypertension undergoing angiotensin\u2010converting enzyme inhibitor and\/or angiotensin receptor blockers drug therapy may be at a higher risk of contracting a serious COVID\u201019 infection and should be monitored. Moreover, in the present study we investigated the effects of angiotensin\u2010converting enzyme inhibitor versus angiotensin receptor blockers versus calcium channel blockers on clinical outcomes as mechanical ventilation, intensive care unit admissions, heart injury, and death in 62 patients with hypertension hospitalized for COVID\u201019 infection.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>METHODS AND RESULTS<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The multicenter study was prospectively conducted at Department of Infectious Diseases of Sant'Anna Hospital of Caserta, and of University of Campania \"Luigi Vanvitelli\" of Naples, at Department of Advanced Surgical and Medical Sciences of University of Campania \"Luigi Vanvitelli,\" Naples, and at General Medical Assistance Unit \"FIMG,\" Naples, Italy. Lowest values of left ventricle ejection fraction predicted deaths (1.142, 1.008\u20131.294,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05), while highest values of interleukin\u20106 predicted the admission to intensive care unit (1.617, 1.094\u20132.389), mechanical ventilation (1.149, 1.082\u20131.219), heart injuries (1.367, 1.054\u20131.772), and deaths (4.742, 1.788\u20138.524).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>CONCLUSIONS<\/jats:title>\n            <jats:p xml:lang=\"en\">Anti\u2010hypertensive drugs didn't affect the prognosis in patients with COVID\u201019. Consequently, tailored anti\u2010inflammatory and immune therapies in addition to chronic antihypertensive therapy, could prevent a worse prognosis, as well as improve the clinical outcomes in patients with hypertension with COVID\u201019 infection.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.016948","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T09:32:47Z","timestamp":1594114367000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":72,"title":["Could Anti\u2010Hypertensive Drug Therapy Affect the Clinical Prognosis of Hypertensive Patients With COVID\u201019 Infection? Data From Centers of Southern Italy"],"prefix":"10.1161","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5099-3790","authenticated-orcid":false,"given":"Celestino","family":"Sardu","sequence":"first","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences University of Campania \u201cLuigi Vanvitelli\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Maggi","sequence":"additional","affiliation":[{"name":"Department of Mental Health and Physics and Preventive Medicine University of Campania \u201cLuigi Vanvitelli\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1323-5127","authenticated-orcid":false,"given":"Vincenzo","family":"Messina","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Sant\u2019 Anna Hospital Caserta Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Iuliano","sequence":"additional","affiliation":[{"name":"Department of Mental Health and Physics and Preventive Medicine University of Campania \u201cLuigi Vanvitelli\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Sardu","sequence":"additional","affiliation":[{"name":"Federazione Italiana Medicina Generale FIMG Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Iovinella","sequence":"additional","affiliation":[{"name":"Federazione Italiana Medicina Generale FIMG Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Paolisso","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences University of Campania \u201cLuigi Vanvitelli\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3960-9270","authenticated-orcid":false,"given":"Raffaele","family":"Marfella","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences University of Campania \u201cLuigi Vanvitelli\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","unstructured":"Aggiornamento Coronavirus in Italia. ISTAT. Available at: Salute.gov.it Accessed March 15 2020."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2002032"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.04.028"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy339"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0244-8"},{"key":"e_1_3_2_7_2","first-page":"802","article-title":"Association of cardiac injury with mortality in hospitalized patients with COVID\u201019 in Wuhan, China","volume":"5","author":"Shi S","year":"2020","unstructured":"Shi S , Qin M , Shen B , Cai Y , Liu T , Yang F , Gong W , Liu X , Liang J , Zhao Q , et al. Association of cardiac injury with mortality in hospitalized patients with COVID\u201019 in Wuhan, China. JAMA 2020;5:802\u2013810.","journal-title":"JAMA"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9051417"},{"key":"e_1_3_2_9_2","first-page":"S1262\u20103636(20)3","article-title":"Negative impact of hyperglycaemia on tocilizumab therapy in Covid\u201019 patients","author":"Marfella R","year":"2020","unstructured":"Marfella R, Paolisso P, Sardu C, Bergamaschi L, D'Angelo EC, Barbieri M, Rizzo MR, Messina V, Maggi P, Coppola N, et al. Negative impact of hyperglycaemia on tocilizumab therapy in Covid\u201019 patients. Diabetes Metab. 2020:S1262\u20103636(20)30082\u20103.","journal-title":"Diabetes Metab"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-0723"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.120.016948","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:12:54Z","timestamp":1715598774000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.120.016948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":9,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1161\/JAHA.120.016948"],"URL":"https:\/\/doi.org\/10.1161\/jaha.120.016948","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"2020-05-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e016948"}}