{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T07:35:02Z","timestamp":1771918502485,"version":"3.50.1"},"reference-count":61,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,4,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Low cardiorespiratory fitness (CRF) and obesity are risk factors for heart failure but their associations with right ventricular (RV) systolic function and pulmonary artery systolic pressure (PASP) are not well understood.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Participants in the CARDIA (Coronary Artery Risk Development in Young Adults) study who underwent maximal treadmill testing at baseline and had a follow\u2010up echocardiographic examination at year 25 were included. A subset of participants had repeat CRF and body mass index (BMI) assessment at year 20. The associations of baseline and changes in CRF and BMI on follow\u2010up (baseline to year 20) with RV systolic function parameters (tricuspid annular plane systolic excursion, RV Doppler systolic velocity of the lateral tricuspid annulus), and PASP were assessed using multivariable\u2010adjusted linear regression models. The study included 3433 participants. In adjusted analysis, higher baseline BMI but not CRF was significantly associated with higher PASP. Among RV systolic function parameters, higher baseline CRF and BMI were significantly associated with higher tricuspid annular plane systolic excursion and RV systolic velocity of the lateral tricuspid annulus. In the subgroup of participants with follow\u2010up assessment of CRF or BMI at year 20, less decline in CRF was associated with higher RV systolic velocity of the lateral tricuspid annulus and lower PASP, while greater increase in BMI was significantly associated with higher PASP in middle age.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Higher CRF in young adulthood and less decline in CRF over time are each significantly associated with better RV systolic function. Higher baseline BMI and greater age\u2010related increases in BMI are each significantly associated with higher PASP in middle age. These findings provide insights into possible mechanisms through which low fitness and obesity may contribute toward risk of heart failure.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.016968","type":"journal-article","created":{"date-parts":[[2021,3,28]],"date-time":"2021-03-28T09:00:12Z","timestamp":1616922012000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Longitudinal Associations of Fitness and Obesity in Young Adulthood With Right Ventricular Function and Pulmonary Artery Systolic Pressure in Middle Age: The CARDIA Study"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2002-4096","authenticated-orcid":false,"given":"Kershaw V.","family":"Patel","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine University of Texas Southwestern Medical Center Dallas TX"},{"name":"Department of Cardiology Houston Methodist DeBakey Heart &amp; Vascular Center TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Metzinger","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine University of Texas Southwestern Medical Center Dallas TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine University of Texas Southwestern Medical Center Dallas TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norrina","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Feinberg School of Medicine Northwestern University Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colby","family":"Ayers","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine University of Texas Southwestern Medical Center Dallas TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7896-0608","authenticated-orcid":false,"given":"Steven M.","family":"Kawut","sequence":"additional","affiliation":[{"name":"Department of Medicine Perelman School of Medicine University of Pennsylvania Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Sidney","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Northern California Division of Research Oakland CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7988-8361","authenticated-orcid":false,"suffix":"Jr.","given":"David C.","family":"Goff","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Northern California Division of Research Oakland CA"},{"name":"Colorado School of Public Health Aurora CO"},{"name":"Division of Cardiovascular Sciences NHLBI Bethesda MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7232-0543","authenticated-orcid":false,"suffix":"Jr.","given":"David R.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"School of Public Health University of Minnesota Minneapolis MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed F.","family":"Zaky","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine University of Alabama at Birmingham AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7035-0848","authenticated-orcid":false,"given":"Mercedes","family":"Carnethon","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Feinberg School of Medicine Northwestern University Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarett D.","family":"Berry","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine University of Texas Southwestern Medical Center Dallas TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9651-3836","authenticated-orcid":false,"given":"Ambarish","family":"Pandey","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine University of Texas Southwestern Medical Center Dallas TX"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.10.056"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.112.000054"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.116.003780"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2014.10.017"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2018.09.006"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.044865"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2016.12.021"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.887893"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.807289"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2018.07.004"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2013.09.006"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2017.05.005"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2016.11.014"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.07.031"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2014.01.004"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2009.10.012"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2014.03.001"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.09.028"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.979203"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.112.095216"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.114.001366"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2018.2454"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.838698"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.030617"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.973784"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(87)90008-0"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(88)90080-7"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199202000-00004"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181cf8242"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2009.07.037"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.11.3035"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.6309"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(76)80401-2"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(82)90275-7"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1989.03430170057028"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199803000-00014"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/echo.12832"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.10.005"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.005111"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.05.010"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.016801"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/ejhf.37"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2020.11.004"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.015853"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.11.081"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-54956-8"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-0172"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.115.003810"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.15-403"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc4801.100076"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.08.1037"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.08.2141"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.50.4.451"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2006.04.076"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.64.3.477"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1997.00440420115011"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00193014"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.90599.2008"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.050941"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz713"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.120.016968","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:19:19Z","timestamp":1715599159000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.120.016968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,6]]},"references-count":61,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,4,6]]}},"alternative-id":["10.1161\/JAHA.120.016968"],"URL":"https:\/\/doi.org\/10.1161\/jaha.120.016968","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,6]]},"assertion":[{"value":"2020-04-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e016968"}}