{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:30:29Z","timestamp":1789050629808,"version":"build-2803163510"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Gait speed is a reliable measure of physical function and frailty in patients with aortic stenosis undergoing transcatheter aortic valve replacement (TAVR). Slow gait speed pre\u2010TAVR predicts worse clinical outcomes post\u2010TAVR. The consequences of improved versus worsened physical function post\u2010TAVR are unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The REPRISE III (Repositionable Percutaneous Replacement of Stenotic Aortic Valve Through Implantation of Lotus Valve System\u2013Randomized Clinical Evaluation) trial randomized high\/extreme risk patients to receive a mechanically\u2010expanded or self\u2010expanding transcatheter heart valve. Of 874 patients who underwent TAVR, 576 with complete data at baseline and 1 year were included in this analysis. Slow gait speed in the 5\u2010m walk test was defined as &lt;0.83\u00a0m\/s. A clinically meaningful improvement (\u22650.1\u00a0m\/s) in gait speed 1\u00a0year after TAVR occurred in 39% of patients, 35% exhibited no change, and 26% declined\u00a0(\u22650.1\u00a0m\/s). Among groups defined by baseline\/1\u2010year post\u2010TAVR gait speeds, 1\u2010 to 2\u2010year mortality or hospitalization rates were as follows: 6.6% (normal\/normal), 8.0% (slow\/normal), 20.9% (normal\/slow), and 21.5% (slow\/slow). After adjustment, slow gait speed at 1\u00a0year (regardless of baseline speed) was associated with a 3.5\u2010fold increase in death\/hospitalization between 1 and 2\u00a0years compared with those with normal baseline\/1\u2010year gait speed. Patients whose slow gait speed normalized at 1\u00a0year had no increased risk. One\u2010year, but not baseline, gait speed was associated with death or hospitalization between 1 and 2\u00a0years (adjusted hazard ratio, 0.83 per 0.1\u00a0m\/s faster gait; 95% CI, 0.74\u20130.93,\n              <jats:italic>P<\/jats:italic>\n              =0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Marked heterogeneity exists in the trajectory of physical function after TAVR and this, more than baseline function, has clinical consequences. Identifying and optimizing factors associated with physical resilience after TAVR may improve outcomes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clini\u200bcaltr\u200bials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT02202434.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.017075","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T09:10:14Z","timestamp":1598605814000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["Clinical Implications of Physical Function and Resilience in Patients Undergoing Transcatheter Aortic Valve Replacement"],"prefix":"10.1161","volume":"9","author":[{"given":"Kashish","family":"Goel","sequence":"first","affiliation":[{"name":"Structural Heart and Valve Center Vanderbilt University Medical Center Nashville TN"},{"name":"Cardiovascular Medicine Division Vanderbilt University Medical Center Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared M.","family":"O\u2019Leary","sequence":"additional","affiliation":[{"name":"Structural Heart and Valve Center Vanderbilt University Medical Center Nashville TN"},{"name":"Cardiovascular Medicine Division Vanderbilt University Medical Center Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7904-0501","authenticated-orcid":false,"given":"Colin M.","family":"Barker","sequence":"additional","affiliation":[{"name":"Structural Heart and Valve Center Vanderbilt University Medical Center Nashville TN"},{"name":"Cardiovascular Medicine Division Vanderbilt 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