{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:36:25Z","timestamp":1787960185366,"version":"build-2784847793"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Recent data have suggested a substantial incidence of atrial arrhythmias (AAs) in cardiac sarcoidosis (CS). Our study aims were to first assess how often AAs are the presenting feature of previously undiagnosed CS. Second, we used prospective follow\u2010up data from implanted devices to investigate AA incidence, burden, predictors, and response to immunosuppression.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">This project is a substudy of the CHASM\u2010CS (Cardiac Sarcoidosis Multicenter Prospective Cohort Study; NCT01477359). Inclusion criteria were presentation with clinically manifest cardiac sarcoidosis, treatment\u2010naive status, and implanted with a device that reported accurate AA burden. Data were collected at each device interrogation visit for all patients and all potential episodes of AA were adjudicated. For each intervisit period, the total AA burden was obtained. A total of 33 patients met the inclusion criteria (aged 56.1\u00b17.7\u00a0years, 45.5% women). Only 1 patient had important AAs as a part of the initial CS presentation. During a median follow\u2010up of 49.1\u00a0months, 11 of 33 patients (33.3%) had device\u2010detected AAs, and only 2 (6.1%) had a clinically significant AA burden. Both patients had reduced burden after CS was successfully treated and there was no residual fluorodeoxyglucose uptake on positron emission tomography scan.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">First, we found that AAs are a rare presenting feature of clinically manifest cardiac sarcoidosis. Second, AAs occurred in a minority of patients at follow\u2010up; the burden was very low in most patients. Only 2 patients had clinically significant AA burden, and both had a reduction after CS was treated.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clini\u200bcaltr\u200bials.gov<\/jats:ext-link>\n              ; unique identifier NCT01477359.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.017086","type":"journal-article","created":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T09:09:48Z","timestamp":1597914588000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Atrial Arrhythmias in Clinically Manifest Cardiac Sarcoidosis: Incidence, Burden, Predictors, and Outcomes"],"prefix":"10.1161","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2848-5295","authenticated-orcid":false,"given":"Willy","family":"Weng","sequence":"first","affiliation":[{"name":"Division of Cardiology University of Ottawa Heart Institute Ottawa ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Wiefels","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Ottawa Heart Institute Ottawa ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0868-0982","authenticated-orcid":false,"given":"Santabhanu","family":"Chakrabarti","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo B.","family":"Nery","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Ottawa Heart Institute Ottawa ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emel","family":"Celiker-Guler","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Ottawa Heart Institute Ottawa ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1216-7580","authenticated-orcid":false,"given":"Jeff S.","family":"Healey","sequence":"additional","affiliation":[{"name":"Population Health Research Institute McMaster University Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz W.","family":"Hruczkowski","sequence":"additional","affiliation":[{"name":"Mazankowski Alberta Heart Institute University of Alberta Edmonton AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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