{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:58:53Z","timestamp":1792515533141,"version":"4.5.0"},"reference-count":146,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,11,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Coronary artery bypass grafting (CABG) is known to improve heart function and quality of life, while rates of surgery\u2010related mortality are low. However, delirium and cognitive decline are common complications. We sought to identify preoperative, intraoperative, and postoperative risk or protective factors associated with delirium and cognitive decline (across time) in patients undergoing CABG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">We conducted a systematic search of Medline, PsycINFO, EMBASE, and Cochrane (March 26, 2019) for peer\u2010reviewed, English publications reporting post\u2010CABG delirium or cognitive decline data, for at least one risk factor. Random\u2010effects meta\u2010analyses estimated pooled odds ratio for categorical data and mean difference or standardized mean difference for continuous data. Ninety\u2010seven studies, comprising data from 60\u00a0479 patients who underwent CABG, were included. Moderate to large and statistically significant risk factors for delirium were as follows: (1) preoperative cognitive impairment, depression, stroke history, and higher European System for Cardiac Operative Risk Evaluation (EuroSCORE) score, (2) intraoperative increase in intubation time, and (3) postoperative presence of arrythmia and increased days in the intensive care unit; higher preoperative cognitive performance was protective for delirium. Moderate to large and statistically significant risk factors for acute cognitive decline were as follows: (1) preoperative depression and older age, (2) intraoperative increase in intubation time, and (3) postoperative presence of delirium and increased days in the intensive care unit. Presence of depression preoperatively was a moderate risk factor for midterm (1\u20136\u00a0months) post\u2010CABG cognitive decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">This meta\u2010analysis identified several key risk factors for delirium and cognitive decline following CABG, most of which are nonmodifiable. Future research should target preoperative risk factors, such as depression or cognitive impairment, which are potentially modifiable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.crd.york.ac.uk\/prospero\/\">https:\/\/www.crd.york.ac.uk\/prosp\u200bero\/<\/jats:ext-link>\n                      ; Unique identifier: CRD42020149276.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.120.017275","type":"journal-article","created":{"date-parts":[[2020,11,7]],"date-time":"2020-11-07T05:25:21Z","timestamp":1604726721000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":162,"title":["Risk Factors for Delirium and Cognitive Decline Following Coronary Artery Bypass Grafting Surgery: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1161","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2594-4492","authenticated-orcid":false,"given":"Danielle","family":"Greaves","sequence":"first","affiliation":[{"name":"Cognitive Ageing and Impairment Neurosciences Laboratory, Justice and Society Academic Unit University of South Australia Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Psaltis","sequence":"additional","affiliation":[{"name":"Vascular Research Centre Lifelong Health Theme South Australian Health and Medical Research Institute Adelaide Australia"},{"name":"Adelaide Medical School University of Adelaide Adelaide Australia"},{"name":"Department of Cardiology Royal Adelaide Hospital Central Adelaide Local Health Network Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1560-1955","authenticated-orcid":false,"given":"Daniel H. 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