{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T17:02:53Z","timestamp":1770915773512,"version":"3.50.1"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,10,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Excess visceral adipose tissue (VAT) is a primary driver for the cardiometabolic complications of obesity; VAT\u2010associated cardiovascular disease risk varies by race, but most studies have been done on Non\u2010Hispanics. This study aimed to evaluate the clinical and metabolic correlates of VAT, its association with subclinical atherosclerosis, and the factors affecting this association in Mexican Americans.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Participants (n=527) were drawn from the Cameron County Hispanic Cohort (CCHC), on whom a carotid ultrasound to assess carotid intima media thickness and a dual\u2010energy X\u2010ray absorptiometry scan to assess for VAT were obtained. Those in the highest quartiles of VAT were more likely to have hypertension, hypertriglyceridemia, low high\u2010density lipoprotein, diabetes mellitus, and metabolic syndrome. Increased carotid intima media thickness was more prevalent in those in the highest quartile for VAT (57.4% versus 15.4% for the lowest quartile;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). There was a graded increase in mean carotid intima media thickness with increasing VAT, after adjusting for covariates; for every 10\u00a0cm\n              <jats:sup>2<\/jats:sup>\n              increase in VAT, there was an increase of 0.004\u00a0mm (SE=0.002;\n              <jats:italic>P<\/jats:italic>\n              =0.0299) in mean carotid intima media thickness. However, this association was only seen among second or higher generation US\u2010born Mexican Americans but not among first generation immigrants (\n              <jats:italic>P<\/jats:italic>\n              =0.024).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Excess VAT is associated with indicators of metabolic disorders and subclinical atherosclerosis in Mexican Americans regardless of body mass index. However, acculturation appears to be an important modulator of this association. Longitudinal follow\u2010up with targeted interventions among second or higher generation Hispanics to lower VAT and improve cardiometabolic risk may help prevent premature cardiovascular disease in this cohort.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.017373","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T09:00:27Z","timestamp":1602752427000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Association of Visceral Adipose Tissue and Subclinical Atherosclerosis in US\u2010Born Mexican Americans but not First Generation Immigrants"],"prefix":"10.1161","volume":"9","author":[{"given":"Clarence","family":"Gill","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine at The University of Texas Health Science Center at Houston Houston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4088-304X","authenticated-orcid":false,"given":"Miryoung","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Public Health The University of Texas Health Science Center at Houston Brownsville TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7260-2524","authenticated-orcid":false,"given":"Kristina P.","family":"Vatcheva","sequence":"additional","affiliation":[{"name":"School of Mathematical and Statistical Science The University of Texas at Rio Grande Valley Brownsville TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0075-5836","authenticated-orcid":false,"given":"Nahid","family":"Rianon","sequence":"additional","affiliation":[{"name":"Division of Geriatric Medicine Department of Internal Medicine McGovern Medical School at The University of Texas Health Science Center at Houston Houston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beverly","family":"Smulevitz","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine at The University of Texas Health Science Center at Houston Houston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David D.","family":"McPherson","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine at The University of Texas Health Science Center at Houston Houston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5844-8102","authenticated-orcid":false,"given":"Joseph B.","family":"McCormick","sequence":"additional","affiliation":[{"name":"School of Public Health The University of Texas Health Science Center at Houston Brownsville TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan P.","family":"Fisher\u2010Hoch","sequence":"additional","affiliation":[{"name":"School of Public Health The University of Texas Health Science Center at Houston Brownsville TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6504-6646","authenticated-orcid":false,"given":"Susan T.","family":"Laing","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine at The University of Texas Health Science Center at Houston Houston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.14517"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.3.356"},{"key":"e_1_3_2_4_2","unstructured":"Colby S Ortmann J. 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