{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T17:08:53Z","timestamp":1783098533617,"version":"3.54.6"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,4,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Plasma omega\u20103 polyunsaturated fatty acids (\u03c93\u2010PUFAs) have been shown to be inversely correlated with the risk of cardiovascular death in primary prevention. The risk relationship in the setting of an acute coronary syndrome is less well established.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Baseline plasma \u03c93\u2010PUFA composition (\u03b1\u2010linolenic acid, eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid) was assessed through gas chromatography with flame ionization detection in a case\u2010cohort study involving 203 patients with cardiovascular death, 325 with myocardial infarction, 271 with ventricular tachycardia, and 161 with atrial fibrillation, and a random sample of 1612 event\u2010free subjects as controls from MERLIN\u2010TIMI 36 (Metabolic Efficiency With Ranolazine for Less Ischemia in Non\u2013ST\u2010Elevation\u2010Acute Coronary Syndrome\u2013Thrombolysis in Myocardial Infarction 36), a trial of patients hospitalized with non\u2013ST\u2010segment\u2013elevation \u2010acute coronary syndrome. After inverse\u2010probability\u2010weighted multivariable adjustment including all traditional risk factors, a higher relative proportion of long\u2010chain \u03c93\u2010PUFAs (eicosapentaenoic acid, docosapentaenoic acid, docosahexaenoic acid) were associated with 18% lower odds of cardiovascular death (adjusted [adj] odds ratio [OR] per 1 SD, 0.82; 95% CI, 0.68\u20130.98) that was primarily driven by 27% lower odds of sudden cardiac death (adj OR per 1 SD, 0.73; 95% CI, 0.55\u20130.97). Long\u2010chain \u03c93\u2010PUFA levels in the top quartile were associated with 51% lower odds of cardiovascular death (adj OR 0.49; 95% CI, 0.27\u20130.86) and 63% lower odds of sudden cardiac death (adj OR, 0.37; 95% CI, 0.16\u20130.56). An attenuated relationship was seen for \u03b1\u2010linolenic acid and subsequent odds of cardiovascular (adj OR, 0.92; 95% CI, 0.74\u20131.14) and sudden cardiac death (adj OR, 0.91; 95% CI, 0.67\u20131.25). No significant relationship was observed between any \u03c93\u2010PUFAs and the odds of cardiovascular death unrelated to sudden cardiac death, myocardial infarction, atrial fibrillation, or early post\u2010acute coronary syndrome ventricular tachycardia.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In patients after non\u2013ST\u2010segment\u2013elevation\u2010acute coronary syndrome, plasma long\u2010chain \u03c93\u2010PUFAs are inversely associated with lower odds of sudden cardiac death, independent of traditional risk factors and lipids.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT00099788.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.017401","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T09:00:34Z","timestamp":1618218034000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Plasma Omega\u20103 Fatty Acids and the Risk of Cardiovascular Events in Patients After an Acute Coronary Syndrome in MERLIN\u2010TIMI 36"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6444-8598","authenticated-orcid":false,"given":"Thomas A.","family":"Zelniker","sequence":"first","affiliation":[{"name":"Division of Cardiology Vienna General HospitalMedical University of Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9589-5382","authenticated-orcid":false,"given":"David A.","family":"Morrow","sequence":"additional","affiliation":[{"name":"TIMI Study Group Division of Cardiovascular Medicine Brigham and Women's Hospital and Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7093-7048","authenticated-orcid":false,"given":"Benjamin M.","family":"Scirica","sequence":"additional","affiliation":[{"name":"TIMI Study Group Division of Cardiovascular Medicine Brigham and Women's Hospital and Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5258-1869","authenticated-orcid":false,"given":"Jeremy D.","family":"Furtado","sequence":"additional","affiliation":[{"name":"Department of Nutrition Harvard T. H. Chan School of Public Health Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Guo","sequence":"additional","affiliation":[{"name":"TIMI Study Group Division of Cardiovascular Medicine Brigham and Women's Hospital and Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7958-9492","authenticated-orcid":false,"given":"Dariush","family":"Mozaffarian","sequence":"additional","affiliation":[{"name":"Friedman School of Nutrition Science and Policy Tufts University Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0691-3359","authenticated-orcid":false,"given":"Marc S.","family":"Sabatine","sequence":"additional","affiliation":[{"name":"TIMI Study Group Division of Cardiovascular Medicine Brigham and Women's Hospital and Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8663-0067","authenticated-orcid":false,"given":"Michelle L.","family":"O\u2019Donoghue","sequence":"additional","affiliation":[{"name":"TIMI Study Group Division of Cardiovascular Medicine Brigham and Women's Hospital and Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.02.084"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.06.063"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2016.10.018"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2017.5205"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1812792"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1804989"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1811403"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)07072-5"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000074779.11379.62"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.15.1885"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000069566.78305.33"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2006.01.004"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.16.1775"},{"key":"e_1_3_1_15_2","volume-title":"Chapter 10: Case\u2010Control and Other Study Designs","author":"Epidemiology GL","year":"2014","unstructured":"Epidemiology GL. 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