{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:30:23Z","timestamp":1789648223006,"version":"4.0.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"23","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Total liquid ventilation (TLV) has been shown to prevent neurological damage though ultrafast cooling in animal models of cardiac arrest. We investigated whether its neuroprotective effect could be explained by mitigation of early inflammatory events.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Rabbits were submitted to 10 minutes of ventricular fibrillation. After resuscitation, they underwent normothermic follow\u2010up (control) or ultrafast cooling by TLV and hypothermia maintenance for 3\u00a0hours (TLV). Immune response, survival, and neurological dysfunction were assessed for 3\u00a0days. TLV improved neurological recovery and reduced cerebral lesions and leukocyte infiltration as compared with control (eg, neurological dysfunction score=34\u00b16 versus 66\u00b16% at day 1, respectively). TLV also significantly reduced interleukin\u20106 blood levels during the hypothermic episode (298\u00b1303 versus 991\u00b1471\u00a0pg\/mL in TLV versus control at 3\u00a0hours after resuscitation, respectively), but not after rewarming (752\u00b1563 versus 741\u00b1219\u00a0pg\/mL in TLV versus control at 6\u00a0hours after resuscitation, respectively). In vitro assays confirmed the high temperature sensitivity of interleukin\u20106 secretion. Conversely, TLV did not modify circulating high\u2010mobility group box 1 levels or immune cell recruitment into the peripheral circulation. The link between interleukin\u20106 early transcripts (&lt;8\u00a0hours) and neurological outcome in a subpopulation of the previously described Epo\u2010ACR\u201002 (High Dose of Erythropoietin Analogue After Cardiac Arrest) trial confirmed the importance of this cytokine at the early stages as compared with delayed stages (&gt;8\u00a0hours).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The neuroprotective effect of hypothermic TLV was associated with a mitigation of humoral interleukin\u20106 response. A temperature\u2010dependent attenuation of immune cell reactivity during the early phase of the post\u2013cardiac arrest syndrome could explain the potent effect of rapid hypothermia.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT00999583.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.017413","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T10:00:14Z","timestamp":1605607214000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Ultrafast Hypothermia Selectively Mitigates the Early 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