{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:18:46Z","timestamp":1790032726423,"version":"4.0.1"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"24","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,12,15]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Peripheral artery disease (PAD) is a known risk factor for adverse outcomes in patients undergoing percutaneous coronary intervention. However, in some studies PAD is not an independent risk factor. We sought to examine the independent impact of PAD on a large prospective percutaneous coronary intervention registry.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              From our single\u2010center prospective percutaneous coronary intervention registry, we have retrospectively analyzed 25\u00a0690 patients (years 2004\u20132018). We examined the influence of PAD on short\u2010 and long\u2010term outcomes using both regression and propensity\u2010matched analyses. Patients with documented PAD (n=1610, 6.3% of total) were older (66.7\u00b110.8 versus 65.4\u00b112.1,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01), had higher rates of diabetes mellitus (69.3% versus 46.3%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01), hypertension (92.1% versus 76.1%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01) and renal failure (38.3% versus 18.2%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01). There were no differences in the rates of stable versus acute presentations, but less were treated with Prasugrel and Ticagrelor (3.3% versus 8.0% and 7.9% versus 11.9%, respectively,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001 for both). Both 30\u2010day and 3\u2010year rates of all\u2010cause death and major adverse cardiac events were higher for patients with PAD versus control (4.9% versus 2.1% and 7.3% versus 3.3% death and major adverse cardiac events at 30\u00a0days, respectively; 43.4% versus 29.0% and 55.0% versus 37.8%, respectively at 3\u00a0years,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001 for all). Following multivariate analysis, the presence of PAD was associated with a higher risk of both death (hazard ratio [HR], 1.66; CI 1.52\u20131.83;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and major adverse cardiac events (HR, 1.51; CI, 1.40\u20131.64;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">PAD constitutes an independent risk factor for adverse outcomes in patients undergoing percutaneous coronary intervention. Further studies are needed to ascertain which effective therapies may mitigate this risk.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.017655","type":"journal-article","created":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T11:45:36Z","timestamp":1607341536000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Independent Impact of Peripheral Artery Disease on Percutaneous Coronary Intervention"],"prefix":"10.1161","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0625-7937","authenticated-orcid":false,"given":"Leor","family":"Perl","sequence":"first","affiliation":[{"name":"Department of Cardiology Rabin Medical Center Petach\u2010Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamir","family":"Bental","sequence":"additional","affiliation":[{"name":"Department of Cardiology 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