{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:09:56Z","timestamp":1792735796425,"version":"4.5.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"18","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,9,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Heart failure (HF) is a common complication to atrial fibrillation (AF), leading to rehospitalization and death. Early identification of patients with AF at risk for HF might improve outcomes. We aimed to derive a score to predict 1\u2010year risk of new\u2010onset HF after an emergency department (ED) visit with AF.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">The RE\u2010LY AF (Randomized Evaluation of Long\u2010Term Anticoagulant Therapy) registry enrolled patients with AF presenting to an ED in 47 countries, and followed them for a year. The end point was HF hospitalization and\/or HF death. Among 15\u00a0400 ED patients, 9765 had no prior HF (mean age, 64.9\u00b114.9\u00a0years). Within 1\u00a0year, new\u2010onset HF developed in 6.8% of patients, of whom 21% died of HF. Independent predictors of HF included left ventricular hypertrophy (odds ratio [OR], 1.47; 95% CI, 1.19\u20131.82), valvular heart disease (OR, 1.55; 95% CI, 1.18\u20132.04), smoking (OR, 1.42; 95% CI, 1.12\u20131.78), height (OR, 0.93; 95% CI, 0.90\u20130.95 per 3\u00a0cm), age (OR, 1.11; 95% CI, 1.07\u20131.15 per 5\u00a0years), rheumatic heart disease (OR, 1.77, 95% CI, 1.24\u20132.51), prior myocardial infarction (OR, 1.85; 95% CI, 1.45\u20132.36), remaining in AF at ED discharge (OR, 1.86; 95% CI, 1.46\u20132.36), and diabetes (OR, 1.33; 95% CI, 1.09\u20131.64). A continuous risk prediction score (LVS\u2010HARMED [left ventricular, valvular heart disease, smoking or other tobacco use, height, age, rheumatic heart disease, myocardial infarction, emergency department discharge rhythm, and diabetes]) had good discrimination (C statistic, 0.735; 95% CI, 0.716\u20130.755). Validation was conducted internally using bootstrapping (optimism\u2010corrected C statistic, 0.705) and externally (C statistic, 0.699). The 1\u2010year incidence of HF hospitalization and\/or HF death across quartile groups of the score was 1.1%, 4.5%, 6.9%, and 14.4%, respectively. LVS\u2010HARMED also predicted incident stroke (C statistic, 0.753; 95% CI, 0.728\u20130.778).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The LVS\u2010HARMED score predicts new\u2010onset HF after an ED visit for AF. Preventative strategies should be considered in patients with high LVS\u2010HARMED HF risk.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.017735","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T09:50:39Z","timestamp":1631526639000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["LVS\u2010HARMED Risk Score for Incident Heart Failure in Patients With Atrial Fibrillation Who Present to the Emergency Department: Data from a World\u2010Wide Registry"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2249-8220","authenticated-orcid":false,"given":"Linda S. 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