{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T18:32:46Z","timestamp":1769106766408,"version":"3.49.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,1,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Although occult hemoglobin in feces is universally valued as a screening tool for colorectal cancer (CRC), only few studies investigated the clinical meaning of fecal immunochemical test (FIT) in other diseases. We evaluated the clinical utility of FIT in patients with cardiovascular diseases (namely, ischemic stroke and myocardial infarction [MI]).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Using the National Health Insurance database, participants (aged &gt;50 years) with CRC screening records from 2009 to 2012 were screened and followed up. Subjects with a history of cardiovascular diseases and CRC were excluded. Ischemic stroke, MI, and other comorbidities were defined by\n              <jats:italic>International Classification of Diseases, Tenth Revision<\/jats:italic>\n              (\n              <jats:italic>ICD\u201010<\/jats:italic>\n              ), codes. Age, sex, smoking, alcohol consumption, regular exercise, diabetes mellitus, hypertension, dyslipidemia, and body mass index were adjusted in a multivariate analysis. A total of 6\u00a0277\u00a0446 subjects were eligible for analysis. During the mean 6.79\u00a0years of follow\u2010up, 168\u00a0570 participants developed ischemic stroke, 105\u00a0983 developed MI, and 11\u00a0253 deaths were observed. A multivariate\u2010adjusted model revealed that the risk of ischemic stroke was higher in the FIT\u2010positive population (adjusted hazard ratio [HR], 1.09; 95% CI, 1.07\u20131.11). Similarly, FIT\u2010positive subjects were at an increased risk of MI (adjusted HR, 1.09; 95% CI, 1.06\u20131.12). Moreover, increased all\u2010cause mortality was observed in the FIT\u2010positive population (adjusted HR, 1.15; 95% CI, 1.07\u20131.23). The increased risk remained consistent in the stratified analysis on anemia and CRC status.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Positive FIT findings were associated with ischemic stroke, MI, and mortality. Occult blood in feces may offer more clinical information than its well\u2010known conventional role in CRC screening.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.017783","type":"journal-article","created":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T12:17:22Z","timestamp":1609244242000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Occult Blood in Feces Is Associated With an Increased Risk of Ischemic Stroke and Myocardial Infarction: A Nationwide Population Study"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8994-7465","authenticated-orcid":false,"given":"Jung Min","family":"Moon","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Liver Research InstituteSeoul National University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2764-9339","authenticated-orcid":false,"given":"Hyun Jung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Liver Research InstituteSeoul National University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyungdo","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Statistics and Actuarial Science Soongsil University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2241-3960","authenticated-orcid":false,"given":"Da Hye","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biostatistics College of Medicine The Catholic University of Korea Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Wook","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Liver Research InstituteSeoul National University College of Medicine Seoul Republic of Korea"},{"name":"Department of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hosim","family":"Soh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Liver Research InstituteSeoul National University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seona","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Liver Research InstituteSeoul National University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Ae","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Liver Research InstituteSeoul National University College of Medicine Seoul Republic of Korea"},{"name":"Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jooyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Healthcare Research InstituteSeoul National University Hospital Healthcare System Gangnam Center Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong\u2010Joon","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Liver Research InstituteSeoul National University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Pil","family":"Im","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Liver Research InstituteSeoul National University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Liver Research InstituteSeoul National University College of Medicine Seoul Republic of Korea"},{"name":"Department of Internal Medicine Healthcare Research InstituteSeoul National University Hospital Healthcare System Gangnam Center Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21551"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.5989"},{"key":"e_1_3_1_4_2","first-page":"51","article-title":"European guidelines for quality assurance in colorectal cancer screening and diagnosis: overview and introduction to the full supplement publication","volume":"45","author":"von Karsa L","year":"2013","unstructured":"von Karsa L, Patnick J, Segnan N, Atkin W, Halloran S, Lansdorp\u2010Vogelaar I, Malila N, Minozzi S, Moss S, et al. 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