{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T01:40:59Z","timestamp":1793497259054,"version":"4.5.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,1,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The long\u2010term impact of new\u2010onset postoperative atrial fibrillation (POAF) after coronary artery bypass grafting and the benefit of early\u2010initiated oral anticoagulation (OAC) in patients with POAF are uncertain.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">All patients who underwent coronary artery bypass grafting without preoperative atrial fibrillation in Sweden from 2007 to 2015 were included in a population\u2010based study using data from 4 national registries: SWEDEHEART (Swedish Web System for Enhancement and Development of Evidence\u2010based Care in Heart Disease Evaluated According to Recommended Therapies), National Patient Registry, Dispensed Drug Registry, and Cause of Death Registry. POAF was defined as any new\u2010onset atrial fibrillation during the first 30 postoperative days. Cox regression models (adjusted for age, sex, comorbidity, and medication) were used to assess long\u2010term outcome in patients with and without POAF, and potential associations between early\u2010initiated OAC and outcome. In a cohort of 24\u00a0523 patients with coronary artery bypass grafting, POAF occurred in 7368 patients (30.0%), and 1770 (24.0%) of them were prescribed OAC within 30\u00a0days after surgery. During follow\u2010up (median 4.5\u00a0years, range 0\u20129\u00a0years), POAF was associated with increased risk of ischemic stroke (adjusted hazard ratio [aHR] 1.18 [95% CI, 1.05\u20121.32]), any thromboembolism (ischemic stroke, transient ischemic attack, or peripheral arterial embolism) (aHR 1.16, 1.05\u20121.28), heart failure hospitalization (aHR 1.35, 1.21\u20121.51), and recurrent atrial fibrillation (aHR 4.16, 3.76\u20124.60), but not with all\u2010cause mortality (aHR 1.08, 0.98\u20121.18). Early initiation of OAC was not associated with reduced risk of ischemic stroke or any thromboembolism but with increased risk for major bleeding (aHR 1.40, 1.08\u20121.82).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">POAF after coronary artery bypass grafting is associated with negative prognostic impact. The role of early OAC therapy remains unclear. Studies aiming at reducing the occurrence of POAF and its consequences are warranted.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.017966","type":"journal-article","created":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T13:27:48Z","timestamp":1606742868000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":113,"title":["New\u2010Onset Atrial Fibrillation After Coronary Artery Bypass Grafting and Long\u2010Term Outcome: A Population\u2010Based Nationwide Study From the SWEDEHEART Registry"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9372-4387","authenticated-orcid":false,"given":"Amar","family":"Taha","sequence":"first","affiliation":[{"name":"Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska AcademyUniversity of Gothenburg Sweden"},{"name":"Department of Cardiology Region V\u00e4stra G\u00f6talandSahlgrenska University Hospital Gothenburg 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