{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:39:27Z","timestamp":1788305967264,"version":"build-2803163510"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,11,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">During the severe acute respiratory syndrome Coronavirus 2 pandemic, there has been an increase in hyperinflammatory presentation in previously healthy children with a variety of cardiac manifestations. Our objective is to describe the cardiac manifestations found in an international cohort of 55 pediatric cases with multi\u2010system inflammatory syndrome during the severe acute respiratory syndrome Coronavirus 2 pandemic.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We reviewed data on previously healthy pediatric patients (\u226418\u00a0years) with structurally normal hearts who presented at hospitals in the United States, United Kingdom, Spain, and Pakistan with multi\u2010system inflammatory syndrome in children and had consultation with a pediatric cardiologist. Data collected included demographics, clinical presentation, laboratory values, electrocardiographic abnormalities, echocardiographic findings, and initial therapies. A total of 55 patients presented with multi\u2010system inflammatory syndrome in children. Thirty\u2010five patients (64%) had evidence of decreased left ventricular function, 17 (31%) had valvulitis, 12 (22%) with pericardial effusion, and 11 (20%) with coronary abnormalities. Twenty\u2010seven (49%) required intensive care unit admission and 24 (44%) had evidence of shock. Eleven patients (20%) fulfilled complete Kawasaki disease criteria and had lower NT\u2010proBNP (N\u2010terminal pro\u2010B\u2010type natriuretic peptide), D\u2010dimer, and ferritin levels compared with those who did not fulfill criteria. Electrophysiologic abnormalities occurred in 6 patients and included complete atrioventricular block, transient atrioventricular block, and ventricular tachycardia.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">To our knowledge, we describe the first international cohort of pediatric patients with multi\u2010system inflammatory syndrome in children during the severe acute respiratory syndrome Coronavirus 2 pandemic with a range of cardiac manifestations. This article brings awareness and alertness to the global medical community to recognize these children during the pandemic and understand the need for early cardiology evaluation and follow\u2010up.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.018007","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T09:00:19Z","timestamp":1600765219000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":43,"title":["Cardiac Abnormalities Seen in Pediatric Patients During the Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic: An International Experience"],"prefix":"10.1161","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8186-8471","authenticated-orcid":false,"given":"Bradley C.","family":"Clark","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Pediatrics Children\u2019s Hospital at Montefiore Albert Einstein College of Medicine Bronx 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