{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:36:57Z","timestamp":1789472217069,"version":"build-2803163510"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,2,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">High levels of supraventricular ectopy are associated with greater risk of atrial fibrillation, stroke, and death. Little information is available about differences by race\/ethnicity in the extent of supraventricular ectopy, or about whether high levels of supraventricular ectopy are associated with impaired left atrial (LA) function and LA enlargement.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">In the MESA (Multi\u2010Ethnic Study of Atherosclerosis), 1148 participants (47% men; mean age, 67\u00a0years) had cardiovascular magnetic resonance imaging in 2010 to 2012, followed by 14\u2010day ambulatory electrocardiographic monitoring in 2016 to 2018. We analyzed participant characteristics and cardiovascular magnetic resonance measures of LA function and structure in relation to average count of premature atrial contractions (PACs) per hour and average number of runs per day of supraventricular tachycardia. In adjusted regression analyses, older age, male sex, White race, elevated NT\u2010proBNP (N\u2010terminal pro\u2010B\u2010type natriuretic peptide), and a history of clinically detected atrial fibrillation were associated with more PACs\/hour. Chinese and Hispanic participants had on average fewer PACs\/hour than White participants (Chinese participants, 31% less [95% CI, 8%\u201349%]; Hispanic participants, 38% less [95% CI, 19%\u201352%]). Greater LA total emptying fraction was associated with fewer PACs\/hour (per SD, 16% fewer PACs\/hour [95% CI, 7%\u201325% fewer PACs\/hour]). Larger LA minimum volume was associated with more PACs\/hour (per SD, 7% more PACs\/hour [95% CI, 2%\u201313% more PACs\/hour]). Associations of LA volumes with runs of supraventricular tachycardia\/day were similar in direction but were weaker.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Impaired LA function and LA enlargement were associated with more PACs\/hour on extended ambulatory electrocardiographic monitoring. Measurement of supraventricular ectopy may provide information about the extent of atrial myopathy.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.018093","type":"journal-article","created":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T10:36:25Z","timestamp":1612434985000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Associations of Left Atrial Function and Structure With Supraventricular Ectopy: The Multi\u2010Ethnic Study of Atherosclerosis"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7100-512X","authenticated-orcid":false,"given":"Susan R.","family":"Heckbert","sequence":"first","affiliation":[{"name":"Department of Epidemiology University of Washington Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul N.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Washington Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Austin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Washington Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0700-814X","authenticated-orcid":false,"given":"Lin Yee","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cardiovascular Division University of Minnesota Medical School Minneapolis MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy S.","family":"Post","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology Johns Hopkins University Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharath","family":"Ambale Venkatesh","sequence":"additional","affiliation":[{"name":"Department of Radiology Johns Hopkins University School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5632-8150","authenticated-orcid":false,"given":"Elsayed Z.","family":"Soliman","sequence":"additional","affiliation":[{"name":"Epidemiological Cardiology Research Center Wake Forest University School of Medicine Winston\u2010Salem NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S.","family":"Floyd","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Washington Seattle WA"},{"name":"Department of Medicine University of Washington Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nona","family":"Sotoodehnia","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Washington Seattle WA"},{"name":"Department of Medicine, Division of Cardiology University of Washington Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9897-7076","authenticated-orcid":false,"given":"Richard A.","family":"Kronmal","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Washington Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8756-6995","authenticated-orcid":false,"given":"Joao A. C.","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology Johns Hopkins University Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.112300"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000057981.70380.45"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.001118"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-159-11-201312030-00004"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.05.018"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.008714"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.012004"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.11.013"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf113"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0179947"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-015-0152-y"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2018.07.027"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/pace.13507"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1114248"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.736785"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.09.014"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.2307\/1912934"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/1536867X0800800104"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.006028"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.09.034"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.112.002519"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.119.007698"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.115.004299"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.008435"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jez176"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2019.02.021"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.120.018093","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:01:50Z","timestamp":1715598110000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.120.018093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,16]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,2,16]]}},"alternative-id":["10.1161\/JAHA.120.018093"],"URL":"https:\/\/doi.org\/10.1161\/jaha.120.018093","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,16]]},"assertion":[{"value":"2020-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e018093"}}