{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:29:59Z","timestamp":1753889399609,"version":"3.41.2"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,11,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Right ventricular (RV) dysfunction is a prognostic factor for cardiovascular disease. However, its mechanism and pathophysiology remain unknown. We investigated RV function using RV\u2010specific 3\u2010dimensional (3D)\u2010speckle\u2010tracking echocardiography (STE) in patients with chronic thromboembolic pulmonary hypertension. We also assessed regional wall motion abnormalities in the RV and chronological changes during balloon pulmonary angioplasty (BPA).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Twenty\u2010nine patients with chronic thromboembolic pulmonary hypertension who underwent BPA were enrolled and underwent right heart catheterization and echocardiography before, immediately after, and 6\u00a0months after BPA. Echocardiographic assessment of RV function included both 2\u2010dimensional\u2010STE and RV\u2010specific 3D\u2010STE. Before BPA, global area change ratio measured by 3D\u2010STE was significantly associated with invasively measured mean pulmonary artery pressure and pulmonary vascular resistance (\n              <jats:italic>r<\/jats:italic>\n              =0.671 and\n              <jats:italic>r<\/jats:italic>\n              =0.700, respectively). Dividing the RV into the inlet, apex, and outlet, inlet area change ratio showed strong correlation with mean pulmonary artery pressure and pulmonary vascular resistance before BPA (\n              <jats:italic>r<\/jats:italic>\n              =0.573 and\n              <jats:italic>r<\/jats:italic>\n              =0.666, respectively). Only outlet area change ratio was significantly correlated with troponin T values at 6\u00a0months after BPA (\n              <jats:italic>r<\/jats:italic>\n              =0.470), and its improvement after BPA was delayed compared with the inlet and apex regions. Patients with poor outlet area change ratio were associated with a delay in RV reverse remodeling after treatment.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">RV\u2010specific 3D\u2010STE analysis revealed that 3D RV parameters were novel useful indicators for assessing RV function and hemodynamics in pulmonary hypertension and that each regional RV portion presents a unique response to hemodynamic changes during treatment, implicating that evaluation of RV regional functions might lead to a new guide for treatment strategies.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.018096","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T10:19:25Z","timestamp":1603793965000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Regional Right Ventricular Abnormalities Implicate Distinct Pathophysiological Conditions in Patients With Chronic Thromboembolic Pulmonary Hypertension"],"prefix":"10.1161","volume":"9","author":[{"given":"Hidenori","family":"Moriyama","sequence":"first","affiliation":[{"name":"Department of Cardiology Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Cardiology Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaharu","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Department of Cardiology Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Hiraide","sequence":"additional","affiliation":[{"name":"Department of Cardiology Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Cardiology Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7770-2519","authenticated-orcid":false,"given":"Jin","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Cardiology Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2604-1284","authenticated-orcid":false,"given":"Takashi","family":"Kohno","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kyorin University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Itabashi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Cardiology Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9110-7465","authenticated-orcid":false,"given":"Mitsushige","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Tokai University School of Medicine Tokai University Hachioji Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl477"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2011.06.005"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.02.001"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.08.007"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2015.12.014"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.118.008795","article-title":"Right ventricle\u2010specific three\u2010dimensional wall motion tracking for visualization of regional wall motion abnormality in patients with pulmonary arterial hypertension","volume":"9","author":"Moriyama H","year":"2019","unstructured":"Moriyama H, Murata M, Kataoka M, Kawakami T, Endo J, Kohno T, Itabashi Y, Seo Y, Iwao Y, Fukuda K. 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