{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:47:18Z","timestamp":1780494438927,"version":"3.54.1"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,3,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The hemodynamic effects of cardiac resynchronization therapy in patients with left ventricular assist devices (LVADs) are uncharacterized. We aimed to quantify the hemodynamic effects of different ventricular pacing configurations in patients with LVADs, focusing on short\u2010term changes in load\u2010independent right ventricular (RV) contractility.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Patients with LVADs underwent right heart catheterization during spontaneous respiration without sedation and with pressures recorded at end expiration. Right heart catheterization was performed at different pacemaker configurations (biventricular pacing, left ventricular pacing, RV pacing, and unpaced conduction) in a randomly generated sequence with &gt;3\u00a0minutes between configuration change and hemodynamic assessment. The right heart catheterization operator was blinded to the sequence. RV maximal change in pressure over time normalized to instantaneous pressure was calculated from digitized hemodynamic waveforms, consistent with a previously validated protocol. Fifteen patients with LVADs who were in sinus rhythm were included. Load\u2010independent RV contractility, as assessed by RV maximal change in pressure over time normalized to instantaneous pressure, was higher in biventricular pacing compared with unpaced conduction (15.7\u00b17.6 versus 11.0\u00b14.0\u00a0s\n              <jats:sup>\u22121<\/jats:sup>\n              ;\n              <jats:italic>P<\/jats:italic>\n              =0.003). Thermodilution cardiac output was higher in biventricular pacing compared with unpaced conduction (4.48\u00b10.7 versus 4.38\u00b10.8 L\/min;\n              <jats:italic>P<\/jats:italic>\n              =0.05). There were no significant differences in heart rate, ventricular filling pressures, or atrioventricular valvular regurgitation across all pacing configurations.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Biventricular pacing acutely improves load\u2010independent RV contractility in patients with LVADs. Even in these patients with mechanical left ventricular unloading via LVAD who were relative pacing nonresponders (required LVAD support despite cardiac resynchronization therapy), biventricular pacing was acutely beneficial to RV contractility.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.018127","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T10:00:14Z","timestamp":1614938414000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Acute Hemodynamic Effects of Cardiac Resynchronization Therapy Versus Alternative Pacing Strategies in Patients With Left Ventricular Assist Devices"],"prefix":"10.1161","volume":"10","author":[{"given":"Brett","family":"Tomashitis","sequence":"first","affiliation":[{"name":"Department of Medicine Medical University of South Carolina Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalin F.","family":"Baicu","sequence":"additional","affiliation":[{"name":"Division of CardiologyDepartment of MedicineRalph H. Johnson Department of Veterans Affairs Medical Center Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross A.","family":"Butschek","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Medical University of South Carolina Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory R.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Division of CardiologyDepartment of MedicineRalph H. Johnson Department of Veterans Affairs Medical Center Charleston SC"},{"name":"Division of Cardiology Department of Medicine Medical University of South Carolina Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Winterfield","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Medical University of South Carolina Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9045-7722","authenticated-orcid":false,"given":"Ryan J.","family":"Tedford","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Medical University of South Carolina Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7076-221X","authenticated-orcid":false,"given":"Michael R.","family":"Zile","sequence":"additional","affiliation":[{"name":"Division of CardiologyDepartment of MedicineRalph H. Johnson Department of Veterans Affairs Medical Center Charleston SC"},{"name":"Division of Cardiology Department of Medicine Medical University of South Carolina Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4579-0216","authenticated-orcid":false,"given":"Michael R.","family":"Gold","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Medical University of South Carolina Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6188-8072","authenticated-orcid":false,"given":"Brian A.","family":"Houston","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Medical University of South Carolina Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013168"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032423"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050496"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc0402.102623"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.25.3053"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009540"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0906431"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.08.027"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.09.043"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.000112"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.743120"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2012.07.025"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2014.12.006"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.009091"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.09.013"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.05.050"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01904-2018"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13239-013-0124-z"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2018.01.017"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000787"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2018.09.022"},{"key":"e_1_3_1_23_2","volume-title":"Mechanical Circulatory Support for Advanced Heart Failure: A Texas Heart Institute\/Baylor College of Medicine Approach","author":"Morgan JA","year":"2017","unstructured":"Morgan JA, Civitello AB, Frazier OH. Mechanical Circulatory Support for Advanced Heart Failure: A Texas Heart Institute\/Baylor College of Medicine Approach. Cham, Switzerland: Springer; 2017."},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.01.1225"},{"key":"e_1_3_1_25_2","first-page":"H1514","article-title":"Significant left ventricular contribution to right ventricular systolic function","volume":"261","author":"Damiano RJ","year":"1991","unstructured":"Damiano RJ Jr, La Follette P, Jr CJL, Lowe JE, Santamore WP. Significant left ventricular contribution to right ventricular systolic function. Am J Physiol. 1991;261:H1514\u2013H1524.","journal-title":"Am J Physiol"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2006.02.011"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(69)86429-5"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0146-2806(91)90009-Y"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.653576"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.110.959684"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(17)34500-X"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.85.4.1572"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2018.05.017"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.12.039"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2016.07.003"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.120.018127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:15:21Z","timestamp":1715598921000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.120.018127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,16]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,3,16]]}},"alternative-id":["10.1161\/JAHA.120.018127"],"URL":"https:\/\/doi.org\/10.1161\/jaha.120.018127","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,16]]},"assertion":[{"value":"2020-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e018127"}}