{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T02:32:54Z","timestamp":1769826774893,"version":"3.49.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,10,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Elevated natriuretic peptides (NP) are associated with adverse cerebrovascular conditions including stroke, cerebral small vessel disease, and dementia. However, the mechanisms underlying these associations remain unclear. In this study, we examined the relationship of NT\u2010proBNP (N\u2010terminal pro brain NP) and NT\u2010proANP (N\u2010terminal pro atrial NP) with cerebrovascular function, measured by cerebral autoregulation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We included 154 participants (mean age 56\u00b14\u00a0years old) from the CARDIA (Coronary Artery Risk Development in Young Adults) cohort. NT\u2010proBNP and NT\u2010proANP were measured in blood samples from the year 25 examination using electrochemiluminescence Immunoassay and enzyme\u2010linked immunoassay, respectively. Dynamic cerebral autoregulation (dCA) was assessed at the year 30 examination by transcranial Doppler ultrasound, using transfer function analysis (phase and gain) of spontaneous blood pressure and flow velocity oscillations, where lower phase and higher gain reflect less efficient cerebral autoregulation. We used multivariable linear regression models adjusted for demographics, vascular risk factors, and history of kidney and cardiac diseases. Higher NT\u2010proBNP levels at year 25 were associated with lower phase (\u03b2 [95% CI]=\u22125.30 lower degrees of phase [\u221210.05 to \u22120.54]) and higher gain (\u03b2 [95% CI]=0.06 higher cm\/s per mm\u00a0Hg of gain [0.004\u20130.12]) at year 30. Similarly, higher NT\u2010proANP levels were associated with lower phase (\u03b2 [95% CI]=\u22129.08 lower degrees of phase [\u221216.46 to \u22121.70]).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Higher circulating levels of NT\u2010proBNP and NT\u2010proANP are associated with less efficient dCA 5\u00a0years later. These findings link circulating NP to cerebral autoregulation and may be one mechanism tying NP to adverse cerebrovascular outcomes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.018203","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T09:02:13Z","timestamp":1602838933000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["N\u2010Terminal Pro Brain, N\u2010Terminal Pro Atrial Natriuretic Peptides, and Dynamic Cerebral Autoregulation"],"prefix":"10.1161","volume":"9","author":[{"given":"Simin","family":"Mahinrad","sequence":"first","affiliation":[{"name":"Department of Neurology Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1176-9152","authenticated-orcid":false,"given":"Behnam","family":"Sabayan","sequence":"additional","affiliation":[{"name":"Department of Neurology Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaney R.","family":"Garner","sequence":"additional","affiliation":[{"name":"Department of Neurology Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald M.","family":"Lloyd\u2010Jones","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farzaneh A.","family":"Sorond","sequence":"additional","affiliation":[{"name":"Department of Neurology Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2005-0014"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1937-6448(08)00803-4"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.004712"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003423"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)08093-2"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.1.118"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.09.004"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)90191-W"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.7.2078"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00864"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00581.2016"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(87)90008-0"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-11-108"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15626425"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10558-007-9044-6"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.180"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(88)90080-7"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht466"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2004.01.008"},{"key":"e_1_3_2_21_2","first-page":"21","article-title":"Cerebral autoregulation in hypertension and ischemic stroke: a mini review","volume":"2017","author":"Shekhar S","year":"2017","unstructured":"Shekhar S, Liu R, Travis OK, Roman RJ, Fan F. Cerebral autoregulation in hypertension and ischemic stroke: a mini review. J Pharm Sci Exp Pharmacol. 2017;2017:21\u201327.","journal-title":"J Pharm Sci Exp Pharmacol"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00343.2014"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2007.12.003"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.05.022"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1139\/y88-047"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2879355"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2014.07.003"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2017.4207"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031994"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.884866"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.8.1929"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0428"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.07.010"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-474X.2008.00213.x"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/2.6.486"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2003.00885.x"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.05.004"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.9.1686"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.35.5.1119"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1258\/acb.2007.007187"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS19990084"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.120.018203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:56:28Z","timestamp":1715601388000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.120.018203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,20]]},"references-count":40,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2020,10,20]]}},"alternative-id":["10.1161\/JAHA.120.018203"],"URL":"https:\/\/doi.org\/10.1161\/jaha.120.018203","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,20]]},"assertion":[{"value":"2020-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e018203"}}