{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T12:22:42Z","timestamp":1775737362756,"version":"3.50.1"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,3,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Cardiac resynchronization therapy (CRT) is rarely used in patients with congenital heart disease, and reported follow\u2010up is short. We sought to evaluate long\u2010term impact of CRT in a single\u2010center cohort of patients with congenital heart disease.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Thirty\u2010two consecutive patients with structural congenital heart disease (N=30) or congenital atrioventricular block (N=2), aged median of 12.9\u00a0years at CRT with pacing capability device implantation, were followed up for a median of 8.7\u00a0years. CRT response was defined as an increase in systemic ventricular ejection fraction or fractional area of change by &gt;10\u00a0units and improved or unchanged New York Heart Association class. Freedom from cardiovascular death, heart failure hospitalization, or new transplant listing was 92.6% and 83.2% at 5 and 10\u00a0years, respectively. Freedom from CRT complications, leading to surgical system revision (elective generator replacement excluded) or therapy termination, was 82.7% and 72.2% at 5 and 10\u00a0years, respectively. The overall probability of an uneventful therapy continuation was 76.3% and 58.8% at 5 and 10 years, respectively. There was a significant increase in ejection fraction\/fractional area of change (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) mainly attributable to patients with systemic left ventricle (\n              <jats:italic>P<\/jats:italic>\n              =0.002) and decrease in systemic ventricular end\u2010diastolic dimensions (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05) after CRT. New York Heart Association functional class improved from a median 2.0 to 1.25 (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Long\u2010term CRT response was present in 54.8% of patients at last follow\u2010up and was more frequent in systemic left ventricle (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">CRT in patients with congenital heart disease was associated with acceptable survival and long\u2010term response in \u224850% of patients. Probability of an uneventful CRT continuation was modest.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.018302","type":"journal-article","created":{"date-parts":[[2021,3,13]],"date-time":"2021-03-13T10:01:07Z","timestamp":1615629667000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Long\u2010Term Outcome of Patients With Congenital Heart Disease Undergoing Cardiac Resynchronization Therapy"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3489-372X","authenticated-orcid":false,"given":"Peter","family":"Kubu\u0161","sequence":"first","affiliation":[{"name":"Children's Heart Centre 2nd Faculty of Medicine Charles University in Prague and Motol University Hospital Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Rub\u00e1\u010dkov\u00e1 Popelov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Na Homolce Hospital Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4780-6522","authenticated-orcid":false,"given":"Jan","family":"Kovanda","sequence":"additional","affiliation":[{"name":"Children's Heart Centre 2nd Faculty of Medicine Charles University in Prague and Motol University Hospital Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamil","family":"Sedl\u00e1\u010dek","sequence":"additional","affiliation":[{"name":"Cardiology Department Institute for Clinical and Experimental Medicine Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4932-1150","authenticated-orcid":false,"given":"Jan","family":"Janou\u0161ek","sequence":"additional","affiliation":[{"name":"Children's Heart Centre 2nd Faculty of Medicine Charles University in Prague and Motol University Hospital Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050496"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2012.04.026"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013168"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032423"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht150"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001383"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq032"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv741"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr093"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.2174\/157340309787048167"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2008.151266"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.05.009"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.05.096"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2008.160465"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2008.01274.x"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2017.01.015"},{"key":"e_1_3_1_18_2","first-page":"62","volume-title":"Detska Kardiologie","author":"Marek J","year":"2006","unstructured":"Marek J. Echokardiografie. In: Chaloupeck\u00fd V, ed. Detska Kardiologie. Prague, Czech Republic: Galen; 2006:62."},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02337-9"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euw386"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2006.07.034"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2008.00949.x"},{"key":"e_1_3_1_23_2","first-page":"1463","article-title":"Avoiding non\u2010responders to cardiac resynchronization therapy: a practical guide","volume":"38","author":"Daubert C","year":"2017","unstructured":"Daubert C, Behar N, Martins RP, Mabo P, Leclercq C. Avoiding non\u2010responders to cardiac resynchronization therapy: a practical guide. Eur Heart J. 2017;38:1463\u20131472. DOI: 10.1093\/eurheartj\/ehw270","journal-title":"Eur Heart J"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/pace.13670"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.119.007925"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.08.027"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.120.018302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:15:28Z","timestamp":1715598928000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.120.018302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,16]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,3,16]]}},"alternative-id":["10.1161\/JAHA.120.018302"],"URL":"https:\/\/doi.org\/10.1161\/jaha.120.018302","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,16]]},"assertion":[{"value":"2020-09-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e018302"}}