{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:55:04Z","timestamp":1790484904524,"version":"4.1.0"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,4,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Sudden cardiac death (SCD) constitutes a major health problem worldwide. We investigated whether birth weight (BW), small for gestational age (SGA), and large for gestational age are associated with altered risk of SCD among the young (aged 1\u201336\u00a0years).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We included all people born in Denmark from 1973 to 2008 utilizing the Danish Medical Birth Register. All SCDs in Denmark in 2000 to 2009 have previously been identified. We defined 5 BW groups, SGA, and large for gestational age as exposure and SCD as the outcome. We estimated the age\u2010specific relative risk of SCD with 95% CI. Additionally, we investigated if SGA and large for gestational age are associated with pathological findings at autopsy. The study population for the BW analyses comprised 2\u00a0234\u00a0501 people with 389 SCD cases, and the SGA and large for gestational age analyses comprised 1\u00a0786\u00a0281 people with 193 SCD cases. The relative risk for SCD was 6.69 for people with BW between 1500 and 2499\u00a0g (95% CI, 2.38\u201318.80,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and 5.89 for people with BW \u22654500\u00a0g (95% CI, 1.81\u201319.12,\n              <jats:italic>P<\/jats:italic>\n              =0.003) at age 5\u00a0years. BW 2500 to 3400\u00a0g was the reference group. Compared with an appropriate gestational age, the relative risk for SGA was 2.85 (95% CI, 1.35\u20136.00,\n              <jats:italic>P<\/jats:italic>\n              =0.006) at age 10\u00a0years. For the autopsied cases, the relative risk of sudden arrhythmic death syndrome at age 5\u00a0years was 4.19 for SGA (95% CI, 1.08\u201316.22,\n              <jats:italic>P<\/jats:italic>\n              =0.038).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">We found an association between BW and SCD in the young, with an increased risk among SGA infants. In addition, we found an association between SGA and sudden arrhythmic death syndrome.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.018314","type":"journal-article","created":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T10:20:12Z","timestamp":1616235612000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Low Birth Weight Increases the Risk of Sudden Cardiac Death in the Young: A Nationwide Study of 2.2\u00a0Million People"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7014-1018","authenticated-orcid":false,"given":"Vilde","family":"Waaler Loland","sequence":"first","affiliation":[{"name":"Department of Cardiology Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik Nybye","family":"\u00c5gesen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Hadberg","family":"Lynge","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Pinborg","sequence":"additional","affiliation":[{"name":"Fertility Department Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Jabbari","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peder Emil","family":"Warming","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten Akh\u00f8j","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"},{"name":"Section of Biostatistics University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjarke","family":"Risgaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo Gregers","family":"Winkel","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3895-9316","authenticated-orcid":false,"given":"Jacob","family":"Tfelt\u2010Hansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"},{"name":"Department of Forensic Medicine Faculty of Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc4301.098254"},{"key":"e_1_3_1_3_2","first-page":"807","volume-title":"Braunwald\u2019s Heart Disease: A Textbook of Cardiovascular Medicine","author":"Myerburg RJ","year":"2019","unstructured":"Myerburg RJ, Goldberger JJ. 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