{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:33:44Z","timestamp":1791837224280,"version":"4.3.4"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,1,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Shortening the pain\u2010to\u2010balloon (P2B) and door\u2010to\u2010balloon (D2B) intervals in patients with ST\u2010segment\u2013elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (PPCI) is essential in order to limit myocardial damage. We investigated whether direct admission of PPCI\u2010treated patients with STEMI to the catheterization laboratory, bypassing the emergency department, expedites reperfusion and improves prognosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Consecutive PPCI\u2010treated patients with STEMI included in the ACSIS (Acute Coronary Syndrome in Israel Survey), a prospective nationwide multicenter registry, were divided into patients admitted directly or via the emergency department. The impact of the P2B and D2B intervals on mortality was compared between groups by logistic regression and propensity score matching. Of the 4839 PPCI\u2010treated patients with STEMI, 1174 were admitted directly and 3665 via the emergency department. Respective median P2B and D2B were shorter among the directly admitted patients with STEMI (160 and 35\u00a0minutes) compared with those admitted via the emergency department (210 and 75\u00a0minutes,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Decreased mortality was observed with direct admission at 1 and 2 years and at the end of follow\u2010up (median 6.4\u00a0years,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Survival advantage persisted after adjustment by logistic regression and propensity matching. P2B, but not D2B, impacted survival (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Direct admission of PPCI\u2010treated patients with STEMI decreased mortality by shortening P2B and D2B intervals considerably. However, P2B, but not D2B, impacted mortality. It seems that the D2B interval has reached its limit of effect. Thus, all efforts should be extended to shorten P2B by educating the public to activate early the emergency medical services to bypass the emergency department and allow timely PPCI for the best outcome.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.018343","type":"journal-article","created":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T10:04:15Z","timestamp":1608545055000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":31,"title":["Direct Admission of Patients With ST\u2010Segment\u2013Elevation Myocardial Infarction to the Catheterization Laboratory Shortens Pain\u2010to\u2010Balloon and Door\u2010to\u2010Balloon Time Intervals but Only the Pain\u2010to\u2010Balloon Interval Impacts Short\u2010 and Long\u2010Term Mortality"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2041-2833","authenticated-orcid":false,"given":"Simcha R.","family":"Meisel","sequence":"first","affiliation":[{"name":"Heart InstituteHillel Yaffe Medical Center Hadera Israel"},{"name":"Affiliated to the Bruce Rappaport School of MedicineTechnion\u2010Israel Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kleiner\u2010Shochat","sequence":"additional","affiliation":[{"name":"Heart InstituteHillel Yaffe Medical Center Hadera Israel"},{"name":"Affiliated to the Bruce Rappaport School of MedicineTechnion\u2010Israel Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami","family":"Abu\u2010Fanne","sequence":"additional","affiliation":[{"name":"Heart InstituteHillel Yaffe Medical Center Hadera Israel"},{"name":"Affiliated to the Bruce Rappaport School of MedicineTechnion\u2010Israel Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Frimerman","sequence":"additional","affiliation":[{"name":"Heart InstituteHillel Yaffe Medical Center Hadera Israel"},{"name":"Affiliated to the Bruce Rappaport School of MedicineTechnion\u2010Israel Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9250-596X","authenticated-orcid":false,"given":"Asaf","family":"Danon","sequence":"additional","affiliation":[{"name":"Heart InstituteHillel Yaffe Medical Center Hadera Israel"},{"name":"Affiliated to the Bruce Rappaport School of MedicineTechnion\u2010Israel Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1360-5733","authenticated-orcid":false,"given":"Sa\u2019ar","family":"Minha","sequence":"additional","affiliation":[{"name":"Shamir Medical Center Zerifin Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaniv","family":"Levi","sequence":"additional","affiliation":[{"name":"Heart InstituteHillel Yaffe Medical Center Hadera Israel"},{"name":"Affiliated to the Bruce Rappaport School of MedicineTechnion\u2010Israel Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2059-7583","authenticated-orcid":false,"given":"Alex","family":"Blatt","sequence":"additional","affiliation":[{"name":"Kaplan Medical Center Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jameel","family":"Mohsen","sequence":"additional","affiliation":[{"name":"Heart InstituteHillel Yaffe Medical Center Hadera Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avraham","family":"Shotan","sequence":"additional","affiliation":[{"name":"Heart InstituteHillel Yaffe Medical Center Hadera Israel"},{"name":"Affiliated to the Bruce Rappaport School of MedicineTechnion\u2010Israel Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4628-1840","authenticated-orcid":false,"given":"Ariel","family":"Roguin","sequence":"additional","affiliation":[{"name":"Heart InstituteHillel Yaffe Medical Center Hadera Israel"},{"name":"Affiliated to the Bruce Rappaport School of MedicineTechnion\u2010Israel Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.22.2941"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.1.14"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002339"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09963-4"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02320-2"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy394"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.57"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v042.i07"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2006.08.009"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.110.942631"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/joic.12192"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.12.072"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b1807"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-302536"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2011.02.012"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra065985"}],"container-title":["Journal 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