{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:59:31Z","timestamp":1790013571945,"version":"4.0.1"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"24","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,12,15]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Atrial fibrillation (AF) is a risk factor for cognitive decline, possibly from silent brain infarction. Left atrial changes in structure or function (atrial cardiopathy) can lead to AF but may impact cognition independently. It is unknown if AF or atrial cardiopathy also acts on Alzheimer disease\u2013specific mechanisms, such as deposition of \u03b2\u2010amyloid.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A total of 316 dementia\u2010free participants from the ARIC (Atherosclerosis Risk in Communities) study underwent florbetapir positron emission tomography, electrocardiography, and 2\u2010dimensional echocardiography. Atrial cardiopathy was defined as \u22651: (1) left atrial volume index &gt;34\u00a0mL\/m\n              <jats:sup>2<\/jats:sup>\n              ; (2) P\u2010wave terminal force &gt;5000 \u00b5V\u00d7ms; and (3) serum NT\u2010proBNP (N\u2010terminal pro\u2010B\u2010type natriuretic peptide) &gt;250\u00a0pg\/mL. Cross\u2010sectional associations between global cortical \u03b2\u2010amyloid (&gt;1.2 standardized uptake value ratio) and adjudicated history of AF and atrial cardiopathy, each, were evaluated using multivariable logistic regression. Participants (mean age, 76\u00a0years) were 56% women and 42% Black individuals. Odds of elevated florbetapir standardized uptake value ratio were significantly increased among those with atrial cardiopathy (odds ratio, 1.81; 95% CI, 1.02\u20133.22) and doubled for those with enlarged left atrial volume index after adjustment for demographics\/risk factors (95% CI, 1.04\u20134.61). There was no association between P\u2010wave terminal force or NT\u2010proBNP and elevated florbetapir standardized uptake value ratio, nor between AF and elevated standardized uptake value ratio.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Among healthy, nondemented community\u2010dwelling older individuals, we report an association between atrial cardiopathy, left atrial volume index, and elevated brain amyloid, by positron emission tomography, without a similar association in individuals with AF. Potential limitations include reverse causation and survival bias. Ongoing work will help determine if changes in cardiac structure and function precede or occur simultaneously with amyloid deposition.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.018399","type":"journal-article","created":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T11:17:45Z","timestamp":1607426265000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Associations Between Atrial Cardiopathy and Cerebral Amyloid: The ARIC\u2010PET Study"],"prefix":"10.1161","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0393-3589","authenticated-orcid":false,"given":"Michelle C.","family":"Johansen","sequence":"first","affiliation":[{"name":"The Johns Hopkins University School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3343-1352","authenticated-orcid":false,"given":"Thomas H.","family":"Mosley","sequence":"additional","affiliation":[{"name":"University of Mississippi Medical Center Jackson MS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6544-066X","authenticated-orcid":false,"given":"David S.","family":"Knopman","sequence":"additional","affiliation":[{"name":"Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean F.","family":"Wong","sequence":"additional","affiliation":[{"name":"Washington University in St. Louis School of Medicine St. Louis MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiadi","family":"Ndumele","sequence":"additional","affiliation":[{"name":"The Johns Hopkins University School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1056-4451","authenticated-orcid":false,"given":"Amil M.","family":"Shah","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D.","family":"Solomon","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9504-1256","authenticated-orcid":false,"given":"Rebecca F.","family":"Gottesman","sequence":"additional","affiliation":[{"name":"The Johns Hopkins University School of Medicine Baltimore 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of the American Heart 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