{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T19:31:36Z","timestamp":1780342296179,"version":"3.54.1"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,3,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The independent prognostic value of troponin and other biomarker elevation among patients with coronavirus disease 2019 (COVID\u201019) are unclear. We sought to characterize biomarker levels in patients hospitalized with COVID\u201019 and develop and validate a mortality risk score.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              An observational cohort study of 1053 patients with COVID\u201019 was conducted. Patients with all of the following biomarkers measured\u2014troponin\u2010I, B\u2010type natriuretic peptide, C\u2010reactive protein, ferritin, and\n              <jats:sc>d<\/jats:sc>\n              \u2010dimer (n=446) \u2014were identified. Maximum levels for each biomarker were recorded. The primary end point was 30\u2010day in\u2010hospital mortality. Multivariable logistic regression was used to construct a mortality risk score. Validation of the risk score was performed using an independent patient cohort (n=440). Mean age of patients was 65.0\u00b115.2\u00a0years and 65.3% were men. Overall, 444 (99.6%) had elevation of any biomarker. Among tested biomarkers, troponin\u2010I \u22650.34\u00a0ng\/mL was the only independent predictor of 30\u2010day mortality (adjusted odds ratio, 4.38;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Patients with a mortality score using hypoxia on presentation, age, and troponin\u2010I elevation, age (HA\n              <jats:sub>2<\/jats:sub>\n              T\n              <jats:sub>2<\/jats:sub>\n              ) \u22653 had a 30\u2010day mortality of 43.7% while those with a score &lt;3 had mortality of 5.9%. Area under the receiver operating characteristic curve of the HA\n              <jats:sub>2<\/jats:sub>\n              T\n              <jats:sub>2<\/jats:sub>\n              score was 0.834 for the derivation cohort and 0.784 for the validation cohort.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Elevated troponin and other biomarker levels are commonly seen in patients hospitalized with COVID\u201019. High troponin levels are a potent predictor of 30\u2010day in\u2010hospital mortality. A simple risk score can stratify patients at risk for COVID\u201019\u2013associated mortality.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.018477","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T09:01:26Z","timestamp":1604048486000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":47,"title":["Troponin and Other Biomarker Levels and Outcomes Among Patients Hospitalized With COVID\u201019: Derivation and Validation of the HA\n            <sub>2<\/sub>\n            T\n            <sub>2<\/sub>\n            COVID\u201019 Mortality Risk Score"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7264-1814","authenticated-orcid":false,"given":"Kevin K.","family":"Manocha","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Cardiology Weill Cornell Medicine \u2013 New York Presbyterian Hospital New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"Kirzner","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology Weill Cornell Medicine \u2013 New York Presbyterian Hospital New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohan","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology Weill Cornell Medicine \u2013 New York Presbyterian Hospital New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8825-0757","authenticated-orcid":false,"given":"Ilhwan","family":"Yeo","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology New York Presbyterian Hospital\u2010Queens Flushing NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley","family":"Peltzer","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology Weill Cornell Medicine \u2013 New York Presbyterian Hospital New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Ang","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology Weill Cornell Medicine \u2013 New York Presbyterian Hospital New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5441-0740","authenticated-orcid":false,"given":"Han A.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology Weill Cornell Medicine \u2013 New York Presbyterian Hospital New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce B.","family":"Lerman","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology Weill Cornell Medicine \u2013 New York Presbyterian Hospital New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika M.","family":"Safford","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine Department of Medicine Weill Cornell Medicine \u2013 New York Presbyterian Hospital New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7474-3737","authenticated-orcid":false,"given":"Parag","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology Weill Cornell Medicine \u2013 New York Presbyterian Hospital New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4574-9360","authenticated-orcid":false,"given":"Jim W.","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology Weill Cornell Medicine \u2013 New York Presbyterian Hospital New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","unstructured":"Center for Systems Science and Engineering Johns Hopkins University . COVID dashboard. https:\/\/coronavirus.jhu.edu\/map.html. Accessed September 15 2020."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30628-0"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2007575"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1585"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2020.1017"},{"key":"e_1_3_2_8_2","first-page":"2070","article-title":"Association of cardiac injury with mortality in hospitalized patients with COVID\u201019 in Wuhan, China","volume":"41","author":"Shi S","year":"2020","unstructured":"Shi S, Qin M, Shen B, Cai Y, Liu T, Yang F, Gong W, Liu X, Liang J, Zhao Q, et al. Association of cardiac injury with mortality in hospitalized patients with COVID\u201019 in Wuhan, China. JAMA Cardiol. 2020;41:2070\u20132079.","journal-title":"JAMA Cardiol"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.06.007"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.05.055"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2010419"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14768"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2020.04.002"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2020.1096"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa288"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2009020"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.2033"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.05.064"},{"key":"e_1_3_2_20_2","unstructured":"Januzzi JL. Troponin and BNP Use in COVID\u201019. 2020. https:\/\/www.acc.org\/latest\u2010in\u2010cardiology\/articles\/2020\/03\/18\/15\/25\/troponin\u2010and\u2010bnp\u2010use\u2010in\u2010covid19. Accessed June 28 2020."},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.047008"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.17023"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.120.018477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:14:43Z","timestamp":1715598883000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.120.018477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,16]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,3,16]]}},"alternative-id":["10.1161\/JAHA.120.018477"],"URL":"https:\/\/doi.org\/10.1161\/jaha.120.018477","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,16]]},"assertion":[{"value":"2020-07-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e018477"}}