{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:24:50Z","timestamp":1792686290645,"version":"4.5.0"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,11,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Conventional right ventricular pacing (RVP) has been associated with an increased incidence of atrial fibrillation (AF). We sought to compare the occurrence of new\u2010onset AF and assessed AF disease progression during long\u2010term follow\u2010up between His bundle pacing (HBP) and RVP.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We included patients undergoing initial dual\u2010chamber pacemaker implants at Rush University Medical Center between January 1, 2016, and June 30, 2019. A total of 360 patients were evaluated, and 225 patients (HBP, n=105; RVP, n=120) were included in the study. Among the 148 patients (HBP, n=72; RVP, n=76) with no history of AF, HBP demonstrated a lower risk of new\u2010onset AF (adjusted hazard ratio [HR], 0.53; 95% CI, 0.28\u20130.99;\n              <jats:italic>P<\/jats:italic>\n              =0.046) compared with traditional RVP. This benefit was observed with His or RVP burden exceeding 20% (HR, 0.29; 95% CI, 0.13\u20130.64;\n              <jats:italic>P<\/jats:italic>\n              =0.002), \u226540% (HR, 0.31;\n              <jats:italic>P<\/jats:italic>\n              =0.007), \u226560% (HR, 0.35;\n              <jats:italic>P<\/jats:italic>\n              =0.015), and \u226580% (HR, 0.40;\n              <jats:italic>P<\/jats:italic>\n              =0.038). There was no difference with His or RV pacing burden &lt;20% (HR, 0.613; 95% CI, 0.213\u20131.864;\n              <jats:italic>P<\/jats:italic>\n              =0.404). In patients with a prior history of AF, there was no difference in AF progression (\n              <jats:italic>P<\/jats:italic>\n              =0.715); however, in a subgroup of patients with a pacing burden \u226540%, HBP demonstrated a trend toward a lower risk of AF progression (HR, 0.19; 95% CI, 0.03\u20131.16;\n              <jats:italic>P<\/jats:italic>\n              =0.072).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">HBP demonstrated a lower risk of new\u2010onset AF compared with RVP, which was primarily observed at a higher pacing burden.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.018478","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T10:11:16Z","timestamp":1605089476000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":39,"title":["Development of New\u2010Onset or Progressive Atrial Fibrillation in Patients With Permanent HIS Bundle Pacing Versus Right Ventricular Pacing: Results From the RUSH HBP Registry"],"prefix":"10.1161","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6826-9231","authenticated-orcid":false,"given":"Venkatesh","family":"Ravi","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Medicine Rush University Medical Center Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Beer","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Geisinger Heart Institute Wilkes\u2010Barre PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz M.","family":"Pietrasik","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine John H Stroger Jr Hospital of Cook County Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian L.","family":"Hanifin","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Rush University Medical Center Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Ooms","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Rush University Medical Center Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Talha","family":"Ayub","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Rush University Medical Center Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Larsen","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Rush University Medical Center Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4103-4317","authenticated-orcid":false,"given":"Henry D.","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Rush University Medical Center Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9534-349X","authenticated-orcid":false,"given":"Kousik","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Rush University Medical Center Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0889-411X","authenticated-orcid":false,"given":"Richard G.","family":"Trohman","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Rush University Medical Center Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2230-100X","authenticated-orcid":false,"given":"Pugazhendhi","family":"Vijayaraman","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Geisinger Heart Institute Wilkes\u2010Barre PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7999-476X","authenticated-orcid":false,"given":"Parikshit S.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Rush University Medical Center Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000072769.17295.B1"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.05.040"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.10.021"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.02.048"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv268"},{"key":"e_1_3_2_7_2","first-page":"e382","article-title":"2018 ACC\/AHA\/HRS Guideline on the evaluation and management of patients with bradycardia and cardiac conduction delay: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines, and the Heart Rhythm Society","author":"Kusumoto FM","year":"2019","unstructured":"Kusumoto FM, Schoenfeld MH, Barrett C, Edgerton JR, Ellenbogen 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Impact of physiologic pacing versus right ventricular pacing among patients with left ventricular ejection fraction greater than 35%: a systematic review for the 2018 ACC\/AHA\/HRS Guideline on the evaluation and management of patients with bradycardia and cardiac conduction delay: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. 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