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We aimed to synthesize the evidence on the effect of chronic hypertension\/antihypertensive treatment on adverse pregnancy outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Medline\/PubMed, EMBASE, and Web of Science were searched; we included observational studies and assessed the effect of race\/ethnicity, where possible, following a registered protocol (CRD42019120088). Random\u2010effects meta\u2010analyses were used. A total of 81 studies were identified on chronic hypertension, and a total of 16 studies were identified on antihypertensive treatment. Chronic hypertension was associated with higher odds of preeclampsia (adjusted odd ratio [aOR], 5.43; 95% CI, 3.85\u20137.65); cesarean section (aOR, 1.87; 95% CI, 1.6\u20132.16); maternal mortality (aOR, 4.80; 95% CI, 3.04\u20137.58); preterm birth (aOR, 2.23; 95% CI, 1.96\u20132.53); stillbirth (aOR, 2.32; 95% CI, 2.22\u20132.42); and small for gestational age (SGA) (aOR, 1.96; 95% CI, 1.6\u20132.40). Subgroup analyses indicated that maternal race\/ethnicity does not influence the observed associations. Women with chronic hypertension on antihypertensive treatment (versus untreated) had higher odds of SGA (aOR, 1.86; 95% CI, 1.38\u20132.50).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Chronic hypertension is associated with adverse pregnancy outcomes, and these associations appear to be independent of maternal race\/ethnicity. In women with chronic hypertension, those on treatment had a higher risk of SGA, although the number of studies was limited. This could result from a direct effect of the treatment or because severe hypertension during pregnancy is a risk factor for SGA and women with severe hypertension are more likely to be treated. The effect of antihypertensive treatment on SGA needs to be further tested with large randomized controlled trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.120.018494","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T16:01:29Z","timestamp":1624291289000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":69,"title":["Impact of Chronic Hypertension and Antihypertensive Treatment on Adverse Perinatal Outcomes: Systematic Review and Meta\u2010Analysis"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7212-2304","authenticated-orcid":false,"given":"Sukainah Y.","family":"Al Khalaf","sequence":"first","affiliation":[{"name":"School of Public Health University College Cork Cork Ireland"},{"name":"INFANT Research Centre University College Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6802-9956","authenticated-orcid":false,"given":"\u00c9ilis J.","family":"O'Reilly","sequence":"additional","affiliation":[{"name":"School of Public Health University College Cork Cork Ireland"},{"name":"Department of Nutrition Harvard T.H. Chan School of Public Health Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9637-9603","authenticated-orcid":false,"given":"Peter M.","family":"Barrett","sequence":"additional","affiliation":[{"name":"School of Public Health University College Cork Cork Ireland"},{"name":"INFANT Research Centre University College Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8839-3934","authenticated-orcid":false,"given":"Debora F.","family":"B. 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