{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:49:31Z","timestamp":1792000171100,"version":"4.4.0"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,10,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Long QT has been associated with ventricular dysrhythmias, cardiovascular disease (CVD) mortality, and sudden cardiac death. However, no studies to date have investigated the dynamics of within\u2010person QT change over time in relation to risk of incident CVD and all\u2010cause mortality in a real\u2010world setting.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">A cohort study among members of an integrated health care delivery system in Northern California including 61\u00a0455 people (mean age, 62\u00a0years; 60% women, 42% non\u2010White) with 3 or more ECGs (baseline in 2005\u20132009; mean\u00b1SD follow\u2010up time, 7.6\u00b12.6\u00a0years). In fully adjusted models, tertile 3 versus tertile 1 of average QT corrected (using the Fridericia correction) was associated with cardiac arrest (hazard ratio [HR], 1.66), heart failure (HR, 1.62), ventricular dysrhythmias (HR, 1.56), all CVD (HR, 1.31), ischemic heart disease (HR, 1.28), total stroke (HR, 1.18), and all\u2010cause mortality (HR, 1.24). Tertile 3 versus tertile 2 of the QT corrected linear slope was associated with cardiac arrest (HR, 1.22), ventricular dysrhythmias (HR, 1.12), and all\u2010cause mortality (HR, 1.09). Tertile 3 versus tertile 1 of the QT corrected root mean squared error was associated with ventricular dysrhythmias (HR, 1.34), heart failure (HR, 1.28), all\u2010cause mortality (HR, 1.20), all CVD (HR, 1.14), total stroke (HR, 1.08), and ischemic heart disease (HR, 1.07).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Our results demonstrate improved predictive ability for CVD outcomes using longitudinal information from serial ECGs. Long\u2010term average QT corrected was more strongly associated with CVD outcomes than the linear slope or the root mean squared error. This new evidence is clinically relevant because ECGs are frequently used, noninvasive, and inexpensive.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.018513","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T09:08:46Z","timestamp":1632820126000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["QT Interval Dynamics and Cardiovascular Outcomes: A Cohort Study in an Integrated Health Care Delivery System"],"prefix":"10.1161","volume":"10","author":[{"given":"Neha","family":"Mantri","sequence":"first","affiliation":[{"name":"Department of Cardiology Kaiser Permanente San Francisco Medical Center San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Lu","sequence":"additional","affiliation":[{"name":"Division of Research Kaiser Permanente Oakland CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan 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