{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T02:42:11Z","timestamp":1774924931314,"version":"3.50.1"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,4,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Children operated on for a simple congenital heart defect (CHD) are at risk of neurodevelopmental abnormalities. Abnormal cortical development and folding have been observed in fetuses with CHD. We examined whether sulcal folding patterns in adults operated on for simple CHD in childhood differ from those of healthy controls, and whether such differences are associated with neuropsychological outcomes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Patients (mean age, 24.5\u00a0years) who underwent childhood surgery for isolated atrial septal defect (ASD; n=33) or ventricular septal defect (VSD; n=30) and healthy controls (n=37) were enrolled. Sulcal pattern similarity to healthy controls was determined using magnetic resonance imaging and looking at features of sulcal folds, their intersulcal relationships, and sulcal graph topology. The sulcal pattern similarity values were tested for associations with comprehensive neuropsychological scores. Patients with both ASD and VSD had decreased sulcal pattern similarity in the left hemisphere compared with controls. The differences were found in the left temporal lobe in the ASD group and in the whole left hemisphere in the VSD group (\n              <jats:italic>P<\/jats:italic>\n              =0.033 and\n              <jats:italic>P<\/jats:italic>\n              =0.039, respectively). The extent of abnormal left hemispheric sulcal pattern similarity was associated with worse neuropsychological scores (intelligence, executive function, and visuospatial abilities) in the VSD group, and special educational support in the ASD group.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Adults who underwent surgery for simple CHD in childhood display altered left hemisphere sulcal folding patterns, commensurate with neuropsychological scores for patients with VSD and special educational support for ASD. This may indicate that simple CHD affects early brain development.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT03871881.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.018580","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T09:00:13Z","timestamp":1616403613000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Abnormal Left\u2010Hemispheric Sulcal Patterns in Adults With Simple Congenital Heart Defects Repaired in Childhood"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8581-3702","authenticated-orcid":false,"given":"Benjamin","family":"Asschenfeldt","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery Aarhus University Hospital Aarhus N Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus N Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6255-2562","authenticated-orcid":false,"given":"Lars","family":"Evald","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University Aarhus N Denmark"},{"name":"Hammel Neurorehabilitation Centre and University Research Clinic Hammel Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9876-314X","authenticated-orcid":false,"given":"Hyuk Jin","family":"Yun","sequence":"additional","affiliation":[{"name":"Fetal Neonatal Neuroimaging and Developmental Science Center Boston Children's Hospital Boston MA"},{"name":"Division of Newborn Medicine Boston Children's Hospital Boston MA"},{"name":"Harvard Medical School Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7466-5545","authenticated-orcid":false,"given":"Johan","family":"Heiberg","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery Aarhus University Hospital Aarhus N Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus N Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2930-6997","authenticated-orcid":false,"given":"Leif","family":"\u00d8stergaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University Aarhus N Denmark"},{"name":"Center of Functionally Integrative Neuroscience Aarhus University Aarhus C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. Ellen","family":"Grant","sequence":"additional","affiliation":[{"name":"Fetal Neonatal Neuroimaging and Developmental Science Center Boston Children's Hospital Boston MA"},{"name":"Division of Newborn Medicine Boston Children's Hospital Boston MA"},{"name":"Department of Radiology Boston Children's Hospital Boston MA"},{"name":"Harvard Medical School Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8047-0015","authenticated-orcid":false,"given":"Vibeke Elisabeth","family":"Hjortdal","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University Aarhus N Denmark"},{"name":"Department of Cardiothoracic Surgery RigshospitaletCopenhagen Denmark"},{"name":"Institute of Clinical Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiho","family":"Im","sequence":"additional","affiliation":[{"name":"Fetal Neonatal Neuroimaging and Developmental Science Center Boston Children's Hospital Boston MA"},{"name":"Division of Newborn Medicine Boston Children's Hospital Boston MA"},{"name":"Harvard Medical School Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4242-9158","authenticated-orcid":false,"given":"Simon Fristed","family":"Eskildsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University Aarhus N Denmark"},{"name":"Center of Functionally Integrative Neuroscience Aarhus University Aarhus C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.02.020"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.08.036"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.026963"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002302"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.015843"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.05.019"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-3825"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000032908.33237.b1"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067393"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.865568"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs281"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.09.029"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.12.045"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2009.04.003"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1105-17.2017"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.01.005"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn137"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.013051"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.117.006459"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhz101"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhy235"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.04.062"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.10.002"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1117\/12.595145"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/11866763_101"},{"key":"e_1_3_1_27_2","first-page":"409","article-title":"Quantitative comparison of two cortical surface extraction methods using MRI phantoms","volume":"10","author":"Eskildsen SF","year":"2007","unstructured":"Eskildsen SF, \u00d8stergaard LR. 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