{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:40:43Z","timestamp":1792676443591,"version":"4.5.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,2,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">D\u2010dimer is involved in poor outcomes of stroke as a coagulation biomarker. We aimed to investigate the associations of the level and increase in D\u2010dimer between baseline and 90\u00a0days with all\u2010cause death or poor functional outcome in patients after ischemic stroke or transient ischemic attack.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We collected data from the CNSRIII (Third China National Stroke Registry) study. The present substudy included 10\u00a0518 patients within 7\u00a0days (baseline) of ischemic stroke or transient ischemic attack and 6268 patients at 90\u00a0days. Poor functional outcome at 1\u00a0year was assessed on the basis of the modified Rankin Scale (\u22653). Multivariable Cox regression or logistic regression was used to assess the association of D\u2010dimer levels with all\u2010cause death or poor functional outcome. D\u2010dimer levels at 90\u00a0days were lower than those at baseline (1.4\u00a0\u00b5g\/mL versus 1.7\u00a0\u00b5g\/mL;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Higher baseline D\u2010dimer level was associated with all\u2010cause death (adjusted hazard ratio [HR], 1.77; 95% CI, 1.25\u20132.52;\n              <jats:italic>P<\/jats:italic>\n              =0.001) and poor functional outcome (adjusted odds ratio [OR], 1.49; 95% CI, 1.23\u20131.80;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) during 1\u2010year follow\u2010up. Higher D\u2010dimer level at 90\u00a0days was also associated with poor outcomes independently. Furthermore, an increase in D\u2010dimer levels between baseline and 90\u00a0days was associated with all\u2010cause death (since 90\u00a0days to 1\u00a0year after index event) (adjusted HR, 1.99; 95% CI, 1.12\u20133.53;\n              <jats:italic>P<\/jats:italic>\n              =0.019) but not with poor functional outcome (adjusted OR, 1.08; 95% CI, 0.82\u20131.41).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Our study shows that high level and an increase in D\u2010dimer between baseline and 90\u00a0days are associated with poor outcomes in patients after ischemic stroke or transient ischemic attack.<\/jats:p>\n          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