{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:11:05Z","timestamp":1792030265780,"version":"4.4.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,2,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Anti\u2010Sj\u00f6gren's syndrome\u2010related antigen A\u2010antibodies (anti\u2010Ro\/SSA\u2010antibodies) are responsible for a novel form of acquired long\u2010QT syndrome, owing to autoimmune\u2010mediated inhibition of cardiac human ether\u2010a\u2010go\u2010go\u2010related gene\u2010potassium channels. However, current evidence derives only from basic mechanistic studies and relatively small sample\u2010size clinical investigations. Hence, the aim of our study is to estimate the risk of QTc prolongation associated with the presence of anti\u2010Ro\/SSA\u2010antibodies in a large population of unselected subjects.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">This is a retrospective observational cohort study using the Veterans Affairs Informatics and Computing Infrastructure. Participants were veterans who were tested for anti\u2010Ro\/SSA status and had an ECG. Descriptive statistics and univariate and multivariate logistic regression analyses were performed to identify risk factors for heart rate\u2010corrected QT interval (QTc) prolongation. The study population consisted of 7339 subjects (61.4\u00b112.2\u00a0years), 612 of whom were anti\u2010Ro\/SSA\u2010positive (8.3%). Subjects who were anti\u2010Ro\/SSA\u2010positive showed an increased prevalence of QTc prolongation, in the presence of other concomitant risk factors (crude odds ratios [OR], 1.67 [1.26\u20132.21] for QTc &gt;470\/480\u00a0ms; 2.32 [1.54\u20133.49] for QTc &gt;490\u00a0ms; 2.77 [1.66\u20134.60] for QTc &gt;500\u00a0ms), independent of a connective tissue disease history. Adjustments for age, sex, electrolytes, cardiovascular risk factors\/diseases, and medications gradually attenuated QTc prolongation estimates, particularly when QT\u2010prolonging drugs were added to the model. Nevertheless, stepwise\u2010fully adjusted OR for the higher cutoffs remained significantly increased in anti\u2010Ro\/SSA\u2010positive subjects, particularly for QTc &gt;500\u00a0ms (2.27 [1.34\u20133.87]).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Anti\u2010Ro\/SSA\u2010antibody positivity was independently associated with an increased risk of marked QTc prolongation in a large cohort of US veterans. Our data suggest that within the general population individuals who are anti\u2010Ro\/SSA\u2010positive may represent a subgroup of patients particularly predisposed to ventricular arrhythmias\/sudden cardiac death.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.018735","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T12:00:53Z","timestamp":1612353653000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Risk of QTc Interval Prolongation Associated With Circulating Anti\u2010Ro\/SSA Antibodies Among US Veterans: An Observational Cohort Study"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6721-1214","authenticated-orcid":false,"given":"Pietro Enea","family":"Lazzerini","sequence":"first","affiliation":[{"name":"Department of Medical Sciences Surgery and Neurosciences University of Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Cevenini","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies University of Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxia Sarah","family":"Qu","sequence":"additional","affiliation":[{"name":"VA New York Harbor Healthcare SystemSUNY Downstate Medical Center New York NY"},{"name":"Department of Cardiology New York Presbyterian Brooklyn Methodist Hospital Brooklyn NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Fabris","sequence":"additional","affiliation":[{"name":"VA New York Harbor Healthcare SystemSUNY Downstate Medical Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabil","family":"El\u2010Sherif","sequence":"additional","affiliation":[{"name":"VA New York Harbor Healthcare SystemSUNY Downstate Medical Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4149-1785","authenticated-orcid":false,"given":"Maurizio","family":"Acampa","sequence":"additional","affiliation":[{"name":"Stroke Unit University Hospital of Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1818-6275","authenticated-orcid":false,"given":"Alessandra","family":"Cartocci","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies University of Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Laghi\u2010Pasini","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Surgery and Neurosciences University of Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Leopoldo","family":"Capecchi","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Surgery and Neurosciences University of Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Boutjdir","sequence":"additional","affiliation":[{"name":"VA New York Harbor Healthcare SystemSUNY Downstate Medical Center New York NY"},{"name":"NYU School of Medicine New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deana","family":"Lazaro","sequence":"additional","affiliation":[{"name":"VA New York Harbor Healthcare SystemSUNY Downstate Medical Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.108.789081"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192704"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000548"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.16.2041"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.863209"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/pace.13296"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010595"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.61"},{"key":"e_1_3_1_10_2","first-page":"1717","article-title":"Systemic inflammation and arrhythmic risk: lessons from rheumatoid arthritis","volume":"38","author":"Lazzerini PE","year":"2017","unstructured":"Lazzerini PE, Capecchi PL, Laghi\u2010Pasini F. 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