{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:01:27Z","timestamp":1791579687355,"version":"4.3.4"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,4,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Impaired right ventricular (RV) pulmonary artery coupling has been associated with higher mortality in patients with chronic heart disease, but few studies have examined this metric in critically ill patients. We sought to evaluate the association between RV pulmonary artery coupling, defined by the ratio of tricuspid annular peak systolic tissue Doppler velocity (TASV)\/estimated RV systolic pressure (RVSP), and mortality in cardiac intensive care unit patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Using a database of unique cardiac intensive care unit admissions from 2007 to 2018, we included patients with TASV\/RVSP ratio measured within 1\u00a0day of hospitalization. Hospital mortality was analyzed using multivariable logistic regression, and 1\u2010year mortality was analyzed using multivariable Cox proportional\u2010hazards analysis. We included 4259 patients with a mean age of 69\u00b115\u00a0years (40.1% women). Admission diagnoses included acute coronary syndrome in 56%, heart failure in 52%, respiratory failure in 24%, and cardiogenic shock in 12%. The mean TASV\/RVSP ratio was 0.31\u00b10.14, and in\u2010hospital mortality occurred in 7% of patients. Higher TASV\/RVSP ratio was associated with lower in\u2010hospital mortality (adjusted unit odds ratio, 0.68 per each 0.1\u2010unit higher ratio; 95% CI, 0.58\u20130.79;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and lower 1\u2010year mortality among hospital survivors (adjusted unit hazard ratio, 0.83 per each 0.1\u2010unit higher ratio; 95% CI, 0.77\u20130.90;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Stepwise decreases in hospital and 1\u2010year mortality were observed in each higher TASV\/RVSP quintile. The TASV\/RVSP ratio remained associated with mortality after adjusting for left ventricular systolic and diastolic function.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">A low TASV\/RVSP ratio is associated with increased short\u2010term and long\u2010term mortality among cardiac intensive care unit patients, emphasizing importance of impaired RV pulmonary artery coupling as a determinant of poor prognosis. Further study is required to determine whether interventions to optimize RV pulmonary artery coupling can improve outcomes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.019015","type":"journal-article","created":{"date-parts":[[2021,3,28]],"date-time":"2021-03-28T09:02:06Z","timestamp":1616922126000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":50,"title":["Right Ventricular Pulmonary Artery Coupling and Mortality in Cardiac Intensive Care Unit Patients"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6366-2859","authenticated-orcid":false,"given":"Jacob C.","family":"Jentzer","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester Rochester MN"},{"name":"Division of Pulmonary and Critical Care Medicine Mayo Clinic Rochester Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandan S.","family":"Anavekar","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogesh N. V.","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester Rochester MN"},{"name":"Division of Pulmonary and Critical Care Medicine Mayo Clinic Rochester Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis H.","family":"Murphree","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon M.","family":"Wiley","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae K.","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester Rochester 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