{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:50:19Z","timestamp":1792111819877,"version":"4.4.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,3,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The mechanism through which high\u2010density lipoprotein (HDL) induces cardioprotection is not completely understood. We evaluated the correlation between cholesterol efflux capacity (CEC), a functional parameter of HDL, and coronary collateral circulation (CCC). We additionally investigated whether A1BP (apoA1\u2010binding protein) concentration correlates with CEC and CCC.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In this case\u2010control study, clinical and angiographic data were collected from 226 patients (mean age, 58\u00a0years; male, 72%) with chronic total coronary occlusion. CEC was assessed using a radioisotope and J774 cells, and human A1BP concentration was measured using enzyme\u2010linked immunosorbent assay. Differences between the good and poor CCC groups were compared, and associations between CEC, A1BP, and other variables were evaluated. Predictors of CCC were identified by multivariable logistic regression analysis. The CEC was higher in the good than in the poor CCC group (22.0\u00b14.6% versus 20.2\u00b14.7%;\n              <jats:italic>P<\/jats:italic>\n              =0.009). In multivariable analyses including age, sex, HDL\u2010cholesterol levels, age (odds ratio [OR], 0.96;\n              <jats:italic>P<\/jats:italic>\n              =0.003), and CEC (OR, 1.10;\n              <jats:italic>P<\/jats:italic>\n              =0.004) were identified as the independent predictors of good CCC. These relationships remained significant after additional adjustment for diabetes mellitus, acute coronary syndrome, and Gensini score. The A1BP levels were not significantly correlated with CCC (300\u00a0pg\/mL and 283\u00a0pg\/mL in the good CCC and poor CCC groups, respectively,\n              <jats:italic>P<\/jats:italic>\n              =0.25) or CEC.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The relationship between higher CEC and good CCC indicates that well\u2010functioning HDL may contribute to CCC and may be cardioprotective; this suggests that a specific function of HDL can have biological and clinical consequences.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.019060","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T10:05:29Z","timestamp":1614333929000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Cholesterol Efflux and Collateral Circulation in Chronic Total Coronary Occlusion: Effect\u2010Circ Study"],"prefix":"10.1161","volume":"10","author":[{"given":"Seonhwa","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Severance HospitalYonsei University College of MedicineYonsei University Health System Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Mi","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Computing Graduate School Yonsei University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo\u2010Jin","family":"Ann","sequence":"additional","affiliation":[{"name":"Integrative Research Center for Cerebrovascular and Cardiovascular Diseases Yonsei University College of MedicineYonsei University Health System Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moonjong","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Computing Graduate School Yonsei University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Jeong","family":"Cheon","sequence":"additional","affiliation":[{"name":"Integrative Research Center for Cerebrovascular and Cardiovascular Diseases Yonsei University College of MedicineYonsei University Health System Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan Bi","family":"An","sequence":"additional","affiliation":[{"name":"Graduate Program of Science for Aging Graduate School Yonsei University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Ri","family":"Choi","sequence":"additional","affiliation":[{"name":"Graduate Program of Science for Aging Graduate School Yonsei University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Joo","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Severance HospitalYonsei University College of MedicineYonsei University Health System Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaewon","family":"Oh","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Severance HospitalYonsei University College of MedicineYonsei University Health System Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5362-478X","authenticated-orcid":false,"given":"Sungha","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Severance HospitalYonsei University College of MedicineYonsei University Health System Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9856-9227","authenticated-orcid":false,"given":"Seok\u2010Min","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Severance HospitalYonsei University College of MedicineYonsei University Health System Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4535-3745","authenticated-orcid":false,"given":"Sang\u2010Hak","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Severance HospitalYonsei University College of MedicineYonsei University Health System Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00145.2018"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000065118.99409.5F"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-11-143"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2013.207"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr308"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1206797"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.119.312645"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R039297"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvv104"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.07.014"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.2310\/JIM.0b013e31824e980c"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-6-105"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12166"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.092353"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02378-1"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2019.05.012"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001689"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M059865"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.301373"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.10.111"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409065"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000066134.79956.58"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-233874"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.248617"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.26401"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.309754"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.120519"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M083618"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01675-8"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-016-0837-7"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.09.006"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.303454"}],"container-title":["Journal 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