{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:31:24Z","timestamp":1792452684568,"version":"4.5.0"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,5,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">We aimed to investigate the presence and severity of coronary microvascular dysfunction (CMD) in inflammatory bowel disease (IBD) including Crohn disease and ulcerative colitis and to elucidate the influence of surgical resection of the diseased intestines on CMD by assessing coronary flow velocity reserve (CFVR) using transthoracic Doppler echocardiography.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Thirty\u2010seven patients with IBD (aged 44\u00b115\u00a0years; 22 patients with Crohn disease and 15 patients with ulcerative colitis) and 30 controls (aged 46\u00b112\u00a0years) were enrolled. For CFVR measurement, coronary flow velocity was recorded at rest and during hyperemia by ADP infusion using transthoracic Doppler echocardiography, and CFVR &lt;2.5 defined CMD. CFVR measurement was repeated before and within 1\u00a0year after surgery. CFVR was similarly and significantly lower in patients with Crohn disease and those with ulcerative colitis than controls (Crohn disease: 2.92\u00b11.03 [\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05 versus controls], ulcerative colitis: 2.99\u00b10.65 [\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05 versus controls], and controls: 3.84\u00b10.75). Multiple linear regression analysis showed that the presence of IBD and baseline hs\u2010CRP (high\u2010sensitivity C\u2010reactive protein) were independently associated with low CFVR among all study participants (\u03b2=\u22120.403 [\n              <jats:italic>P<\/jats:italic>\n              =0.001] and \u22120.237 [\n              <jats:italic>P<\/jats:italic>\n              =0.037], respectively). Hyperemic coronary flow velocity significantly improved after surgery only in patients with IBD who had CMD. CFVR significantly improved in patients with IBD who had both CMD and non\u2010CMD, and the extent of CFVR improvements were greater in patients with CMD than non\u2010CMD. Multiple linear regression analysis showed that the reduction of hs\u2010CRP was independently associated with improvement of hyperemic coronary flow velocity and CFVR among all patients with IBD (\u03b2=\u22120.481 [\n              <jats:italic>P<\/jats:italic>\n              =0.003] and \u03b2=\u22120.334 [\n              <jats:italic>P<\/jats:italic>\n              =0.043], respectively).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">IBD is associated with CMD, which improved after surgical resection of diseased intestines.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.019125","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T10:53:40Z","timestamp":1619434420000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Coronary Microvascular Dysfunction Restored After Surgery in Inflammatory Bowel Disease: A Prospective Observational Study"],"prefix":"10.1161","volume":"10","author":[{"given":"Kentaro","family":"Kakuta","sequence":"first","affiliation":[{"name":"Department of Cardiology and Nephrology Mie University Graduate School of Medicine Tsu Japan"},{"name":"Department of Cardiology Japan Community Health Care Organization Yokkaichi Hazu Medical Center Yokkaichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5078-6326","authenticated-orcid":false,"given":"Kaoru","family":"Dohi","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Nephrology Mie University Graduate School of Medicine Tsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center Japan Community Health care Organization Yokkaichi Hazu Medical Center Yokkaichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3089-686X","authenticated-orcid":false,"given":"Naoki","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Nephrology Mie University Graduate School of Medicine Tsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Shimoyama","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center Japan Community Health care Organization Yokkaichi Hazu Medical Center Yokkaichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Umegae","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center Japan Community Health care Organization Yokkaichi Hazu Medical Center Yokkaichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Nephrology Mie University Graduate School of Medicine Tsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.08.141"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2014.08.003"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.63"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2006.00242.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(76)80163-1"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000050"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198712243172603"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90621-4"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2015.09.001"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.02.012"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.02.041"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i3.1067"},{"key":"e_1_3_2_14_2","first-page":"1314","article-title":"Pulse wave velocity, intima media thickness, and flow\u2010mediated dilatation in patients with normotensive normoglycemic inflammatory bowel disease","volume":"21","author":"Ozturk K","year":"2015","unstructured":"Ozturk K, Guler AK, Cakir M, Ozen A, Demirci H, Turker T, Demirbas S, Uygun A, Gulsen M, Bagci S. Pulse wave velocity, intima media thickness, and flow\u2010mediated dilatation in patients with normotensive normoglycemic inflammatory bowel disease. Inflamm Bowel Dis. 2015;21:1314\u20131320. DOI: 10.1097\/MIB.0000000000000355.","journal-title":"Inflamm Bowel Dis"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i1.64"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00699-1"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.12.008"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2013.09.021"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.9.890"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.120.019125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:14:17Z","timestamp":1715598857000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.120.019125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,4]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,5,4]]}},"alternative-id":["10.1161\/JAHA.120.019125"],"URL":"https:\/\/doi.org\/10.1161\/jaha.120.019125","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,4]]},"assertion":[{"value":"2020-08-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e019125"}}