{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:29:18Z","timestamp":1782941358166,"version":"3.54.5"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,4,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The menopausal transition is characterized by increased cardiovascular risk, weight gain, and increased adiposity for many women. The adipose\u2010derived secretory proteins adiponectin and leptin are associated with insulin resistance, metabolic syndrome, and cardiovascular disease but their role in subclinical atherosclerotic disease is unclear. This cross\u2010sectional study evaluated the associations of adiponectin and leptin with carotid artery intima\u2010media thickness, adventitial diameter, presence of carotid plaques, and brachial\u2010ankle pulse wave velocity (baPWV) in women aged 54 to 65\u00a0years.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Participants were 1399 women from SWAN (Study of Women's Health Across the Nation), a community\u2010based study of women transitioning through menopause. Carotid ultrasound and baPWV measures were obtained at SWAN follow\u2010up visits 12 or 13, when 97% of participants were post\u2010menopausal. Adipokines were assayed from serum specimens obtained concurrently at these visits. Linear and logistic regression models were used to evaluate adiponectin or leptin, both log\u2010transformed attributable to skewness, in relationship to carotid artery intima\u2010media thickness, adventitial diameter, baPWV, and presence of carotid plaque. Covariates included age, race, study site, smoking, alcohol use, obesity, cardiovascular disease risk factors, and menopausal status. Lower levels of adiponectin were related to greater carotid artery intima\u2010media thickness, wider adventitial diameter, and faster baPWV; associations were attenuated after adjusting for cardiovascular disease risk factors. Higher levels of leptin were associated with greater carotid artery intima\u2010media thickness and wider adventitial diameter in minimally and fully adjusted models, and contrary to expectation, with slower baPWV, particularly among women with diabetes mellitus or obesity.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Adiponectin and leptin are 2 important inflammatory pathways that may contribute to adverse subclinical cardiovascular disease risk profiles in women at midlife.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.019173","type":"journal-article","created":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T10:40:35Z","timestamp":1616841635000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Adipokines and Subclinical Cardiovascular Disease in Post\u2010Menopausal Women: Study of Women's Health Across the Nation"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9839-2537","authenticated-orcid":false,"given":"Susan A.","family":"Everson\u2010Rose","sequence":"first","affiliation":[{"name":"University of Minnesota Minneapolis MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma J. 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