{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:50:05Z","timestamp":1792144205050,"version":"4.4.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,4,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Left ventricular non\u2010compaction remains a poorly described entity, which has led to challenges of overdiagnosis. We aimed to evaluate if the presence of a thin compacted myocardial layer portends poorer outcomes in individuals meeting cardiac magnetic resonance criteria for left ventricular non\u2010compaction .<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      This was an observational, retrospective cohort study involving individuals selected from the Cleveland Clinic Foundation cardiac magnetic resonance database (N=26\u00a0531). Between 2000 and 2018, 328 individuals \u226512\u00a0years, with left ventricular non\u2010compaction or excessive trabeculations based on the cardiac magnetic resonance Petersen criteria were included. The cohort comprised 42% women, mean age 43\u00a0years. We assessed the predictive ability of myocardial thinning for the primary composite end point of major adverse cardiac events (composite of all\u2010cause mortality, heart failure hospitalization, left ventricular assist device implantation\/heart transplant, ventricular tachycardia, or ischemic stroke). At mean follow\u2010up of 3.1\u00a0years, major adverse cardiac events occurred in 102 (31%) patients. After adjusting for comorbidities, the risk of major adverse cardiac events was nearly doubled in the presence of significant compacted myocardial thinning (hazard ratio [HR], 1.88 [95% CI, 1.18\u20123.00];\n                      <jats:italic>P<\/jats:italic>\n                      =0.016), tripled in the presence of elevated plasma B\u2010type natriuretic peptide (HR, 3.29 [95% CI, 1.52\u20127.11];\n                      <jats:italic>P<\/jats:italic>\n                      =0.006), and increased by 5% for every 10\u2010unit increase in left ventricular end\u2010systolic volume (HR, 1.01 [95% CI, 1.00\u20121.01];\n                      <jats:italic>P<\/jats:italic>\n                      =0.041).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">The risk of adverse clinical events is increased in the presence of significant compacted myocardial thinning, an elevated B\u2010type natriuretic peptide or increased left ventricular dimensions. The combination of these markers may enhance risk assessment to minimize left ventricular non\u2010compaction overdiagnosis whilst facilitating appropriate diagnoses in those with true disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.120.019209","type":"journal-article","created":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T06:24:17Z","timestamp":1617949457000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["Novel Approach to Risk Stratification in Left Ventricular Non\u2010Compaction Using A Combined Cardiac Imaging and Plasma Biomarker Approach"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8591-1986","authenticated-orcid":false,"given":"Jay","family":"Ramchand","sequence":"first","affiliation":[{"name":"Heart Vascular and Thoracic Institute Cleveland Clinic Cleveland OH"},{"name":"Imaging InstituteCleveland Clinic Cleveland OH"},{"name":"Department of Medicine Austin HealthThe University of Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Podugu","sequence":"additional","affiliation":[{"name":"Heart Vascular and Thoracic Institute Cleveland Clinic Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Obuchowski","sequence":"additional","affiliation":[{"name":"Heart Vascular and Thoracic Institute Cleveland Clinic Cleveland OH"},{"name":"Imaging InstituteCleveland Clinic Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge C.","family":"Harb","sequence":"additional","affiliation":[{"name":"Heart Vascular and Thoracic Institute Cleveland Clinic Cleveland OH"},{"name":"Imaging InstituteCleveland Clinic Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Chetrit","sequence":"additional","affiliation":[{"name":"Heart Vascular and Thoracic Institute Cleveland Clinic Cleveland OH"},{"name":"Imaging InstituteCleveland Clinic Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0585-1480","authenticated-orcid":false,"given":"Alex","family":"Milinovich","sequence":"additional","affiliation":[{"name":"Heart Vascular and Thoracic Institute Cleveland Clinic Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Griffin","sequence":"additional","affiliation":[{"name":"Heart Vascular and Thoracic Institute Cleveland Clinic Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1863-7539","authenticated-orcid":false,"given":"Louise M.","family":"Burrell","sequence":"additional","affiliation":[{"name":"Department of Medicine Austin HealthThe University of Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8335-735X","authenticated-orcid":false,"given":"W. H.","family":"Wilson Tang","sequence":"additional","affiliation":[{"name":"Heart Vascular and Thoracic Institute Cleveland Clinic Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah H.","family":"Kwon","sequence":"additional","affiliation":[{"name":"Heart Vascular and Thoracic Institute Cleveland Clinic Cleveland OH"},{"name":"Imaging InstituteCleveland Clinic Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4317-9077","authenticated-orcid":false,"given":"Scott D.","family":"Flamm","sequence":"additional","affiliation":[{"name":"Heart Vascular and Thoracic Institute Cleveland Clinic Cleveland OH"},{"name":"Imaging InstituteCleveland Clinic Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.89.8.e21"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.82.2.507"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.174287"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm342"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz317"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.05.096"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.03.045"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.86.6.666"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.08.054"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.08.035"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.119.009712"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000106903.98196.B6"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.084434"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2019.11.008"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-015-0111-7"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.08.053"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.117.006174"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000156"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0225059"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2018.12.029"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.12.019"},{"key":"e_1_3_1_23_2","first-page":"65","article-title":"A simple sequentially rejective multiple test procedure","volume":"6","author":"Holm S","year":"1979","unstructured":"Holm S. 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