{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T10:46:02Z","timestamp":1787222762278,"version":"build-2736575974"},"reference-count":55,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,3,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Electronic hookah (e\u2010hookah) vaping has increased in popularity among youth, who endorse unsubstantiated claims that flavored aerosol is detoxified as it passes through water. However, e\u2010hookahs deliver nicotine by creating an aerosol of fine and ultrafine particles and other oxidants that may reduce the bioavailability of nitric oxide and impair endothelial function secondary to formation of oxygen\u2010derived free radicals.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We examined the acute effects of e\u2010hookah vaping on endothelial function, and the extent to which increased oxidative stress contributes to the vaping\u2010induced vascular impairment. Twenty\u2010six healthy young adult habitual hookah smokers were invited to vape a 30\u2010minute e\u2010hookah session to evaluate the impact on endothelial function measured by brachial artery flow\u2010mediated dilation (FMD). To test for oxidative stress mediation, plasma total antioxidant capacity levels were measured and the effect of e\u2010hookah vaping on FMD was examined before and after intravenous infusion of the antioxidant ascorbic acid (n=11). Plasma nicotine and exhaled carbon monoxide levels were measured before and after the vaping session. Measurements were performed before and after sham\u2010vaping control experiments (n=10). E\u2010hookah vaping, which increased plasma nicotine (+4.93\u00b10.92\u00a0ng\/mL,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001; mean\u00b1SE) with no changes in exhaled carbon monoxide (\u22120.15\u00b10.17\u00a0ppm;\n              <jats:italic>P<\/jats:italic>\n              =0.479), increased mean arterial pressure (11\u00b11\u00a0mm\u00a0Hg,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and acutely decreased FMD from 5.79\u00b10.58% to 4.39\u00b10.46% (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Ascorbic acid infusion, which increased plasma total antioxidant capacity 5\u2010fold, increased FMD at baseline (5.98\u00b10.66% versus 9.46\u00b10.87%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), and prevented the acute FMD impairment by e\u2010hookah vaping (9.46\u00b10.87% versus 8.74\u00b10.84%,\n              <jats:italic>P<\/jats:italic>\n              =0.002). All parameters were unchanged during sham studies.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">E\u2010hookah vaping has adverse effects on vascular function, likely mediated by oxidative stress, which overtime could accelerate development and progression of cardiovascular disease.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/ClinicalTrials.gov\">https:\/\/ClinicalTrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT03690427.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.019271","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T10:56:32Z","timestamp":1613818592000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Ascorbic Acid Prevents Vascular Endothelial Dysfunction Induced by Electronic Hookah (Waterpipe) Vaping"],"prefix":"10.1161","volume":"10","author":[{"given":"Mary","family":"Rezk\u2010Hanna","sequence":"first","affiliation":[{"name":"School of Nursing University of California Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas R.","family":"Seals","sequence":"additional","affiliation":[{"name":"Department of Integrative Physiology University of Colorado Boulder Boulder CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Rossman","sequence":"additional","affiliation":[{"name":"Department of Integrative Physiology University of Colorado Boulder Boulder CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajat","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine David Geffen School of Medicine at University of California Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlie O.","family":"Nettle","sequence":"additional","affiliation":[{"name":"School of Nursing University of California Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelica","family":"Means","sequence":"additional","affiliation":[{"name":"School of Nursing University of California Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Dobrin","sequence":"additional","affiliation":[{"name":"School of Nursing University of California Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiao\u2010Wei","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Nursing University of California Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary\u2010Lynn","family":"Brecht","sequence":"additional","affiliation":[{"name":"School of Nursing University of California Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zab","family":"Mosenifar","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care MedicineCedars\u2010Sinai Medical Center Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus A.","family":"Araujo","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine David Geffen School of Medicine at University of California Los Angeles CA"},{"name":"Department of Environmental Health Sciences Fielding School of Public Health University of California Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal L.","family":"Benowitz","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Research Program Division of Cardiology Department of Medicine University of California San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000107"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6806e1"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2019.05.007"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.857888"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000671"},{"key":"e_1_3_2_7_2","first-page":"953","article-title":"Levels of maximum end\u2010expiratory carbon monoxide and certain cardiovascular parameters following hubble\u2010bubble smoking","volume":"23","author":"Shafagoj YA","year":"2002","unstructured":"Shafagoj YA, Mohammed FI. 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