{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:39:22Z","timestamp":1789778362259,"version":"4.0.1"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"18","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,9,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Current guidelines recommend at least 6\u00a0months of antithrombotic therapy and antibiotic prophylaxis after septal\u2010occluding device deployment in transcatheter closure of atrial septal defect. It has been estimated that it takes \u22486\u00a0months for complete neo\u2010endothelialization; however, neo\u2010endothelialization has not previously been assessed in vivo in humans.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">The neointimal coverage of septal occluder devices was evaluated 6\u00a0months after implantation in 15 patients by angioscopy from the right atrium. Each occluder surface was divided into 9 areas; the levels of endothelialization in each area were semiquantitatively assessed by 4\u2010point grades. Device neo\u2010endothelialization was sufficient in two thirds of patients, but insufficient in one third. In the comparison between patients with sufficiently endothelialized devices of average grade score \u22652 (good endothelialization group, n=10) and those with poorly endothelialized devices of average grade score &lt;2 (poor endothelialization group, n=5), those in the poor endothelialization group had larger devices deployed (27.0 mm [25.0\u201331.5 mm] versus 17.0 mm [15.6\u201322.5 mm], respectively) and progressive right heart dilatation. The endothelialization was poorer around the central areas. Moreover, the prevalence of thrombus formation on the devices was higher in the poorly endothelialized areas than in the sufficiently endothelialized areas (Grade 0, 94.1%; Grade 1, 63.2%; Grade 2, 0%; Grade 3, 1.6%).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Neo\u2010endothelialization on the closure devices varied 6\u00a0months after implantation. Notably, poor endothelialization and thrombus attachment were observed around the central areas and on the larger devices.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.019282","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T09:16:32Z","timestamp":1631870192000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Angioscopic Evaluation of Atrial Septal Defect Closure Device Neo\u2010Endothelialization"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8580-9404","authenticated-orcid":false,"given":"Yasuhiro","family":"Tanabe","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine St. Marianna University School of Medicine Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Division of 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