{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T08:10:55Z","timestamp":1791447055095,"version":"4.3.3"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,3,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The optimal method for communicating coronary heart disease (CHD) risk to individual patients is not yet clear. Recent research supports the concept of \"coronary age\" for more effective risk communication. We defined an individual's coronary age as the age at which an average healthy individual would have an equivalent estimated CHD risk as that calculated for the index individual, building on our previously validated MESA (Multi\u2010Ethnic Study of Atherosclerosis) 10\u2010year CHD Risk Score equations with and without coronary artery calcium (CAC).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We derived a coronary age by (1) calculating the MESA 10\u2010year CHD risk; (2) mathematically setting this equal to an equation describing risk of an average healthy MESA participant, as a function of age; and (3) solving for age. The risk discrimination of the resultant coronary age was compared with that of chronological age, the MESA CHD Risk Score, and CAC alone. Approximately 95% of coronary age values ranged from 30\u00a0years less to 30\u00a0years higher than chronological age. Although the mean chronological age of individuals experiencing CHD events compared with those free of events was 67.4 versus 61.8\u00a0years, the difference in coronary age including CAC was larger (80.6 versus 62.8\u00a0years). Coronary age with CAC had identical predictive ability to that of MESA CHD Risk Score and outperformed chronological age and CAC alone.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The newly derived coronary age is a convenient transformation of MESA CHD Risk, retaining very good risk discrimination. This easy\u2010to\u2010communicate tool will be available for patients and clinicians, potentially facilitating risk communication in routine care.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.019351","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T10:01:14Z","timestamp":1614938474000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":35,"title":["Derivation of a Coronary Age Calculator Using Traditional Risk Factors and Coronary Artery Calcium: The Multi\u2010Ethnic Study of Atherosclerosis"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5138-9683","authenticated-orcid":false,"given":"Michael J.","family":"Blaha","sequence":"first","affiliation":[{"name":"Johns Hopkins Ciccarone Center for Prevention of Cardiovascular Disease Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac N.","family":"Naazie","sequence":"additional","affiliation":[{"name":"Johns Hopkins Ciccarone Center for Prevention of Cardiovascular Disease Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8073-2337","authenticated-orcid":false,"given":"Miguel","family":"Cainzos\u2010Achirica","sequence":"additional","affiliation":[{"name":"Johns Hopkins Ciccarone Center for Prevention of Cardiovascular Disease Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6026-3329","authenticated-orcid":false,"given":"Zeina A.","family":"Dardari","sequence":"additional","affiliation":[{"name":"Johns Hopkins Ciccarone Center for Prevention of Cardiovascular Disease Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"DeFilippis","sequence":"additional","affiliation":[{"name":"University of Louisville KY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn L.","family":"McClelland","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Washington Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadhassan","family":"Mirbolouk","sequence":"additional","affiliation":[{"name":"Department of Medicine Yale New Haven Hospital New Haven CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olusola A.","family":"Orimoloye","sequence":"additional","affiliation":[{"name":"Department of Medicine Vanderbilt University Medical Center Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9483-3510","authenticated-orcid":false,"given":"Omar","family":"Dzaye","sequence":"additional","affiliation":[{"name":"Johns Hopkins Ciccarone Center for Prevention of Cardiovascular Disease Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5376-2269","authenticated-orcid":false,"given":"Khurram","family":"Nasir","sequence":"additional","affiliation":[{"name":"Department of Medicine Yale New Haven Hospital New Haven CT"},{"name":"Division of Cardiovascular Prevention and Wellness Houston Methodist DeBakey Heart &amp; Vascular Center, and Center for Outcomes Research (COR) Houston Methodist Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Page","sequence":"additional","affiliation":[{"name":"Center for Observational Research Amgen Incorporated Thousand Oaks CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.10.007"},{"key":"e_1_3_2_3_2","unstructured":"World Health Organization . 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