{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T11:18:51Z","timestamp":1770549531999,"version":"3.49.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">In cardiovascular outcome trials, the sodium glucose cotransporter 2 inhibitor empagliflozin and glucagon\u2010like peptide\u20101 (GLP\u20101) receptor agonist liraglutide caused similar reductions in major adverse cardiac events (MACE). We compared clinical outcomes in routine clinical care.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">EMPLACE (Cardiovascular and Renal Outcomes, and Mortality in Danish Patients with Type 2 Diabetes Who Initiate Empagliflozin Versus GLP\u20101RA: A Danish Nationwide Comparative Effectiveness Study) is an ongoing nationwide population\u2010based comparative effectiveness cohort study in Denmark. For the present study, we included 14\u00a0498 new users of empagliflozin and 12\u00a0706 new users of liraglutide, 2015 to 2018. Co\u2010primary outcomes were expanded major adverse cardiac events (stroke, myocardial infarction, unstable angina, coronary revascularization, hospitalization for heart failure [HHF], or all\u2010cause death); HHF or all\u2010cause death; and first HHF or first initiation of loop\u2010diuretic therapy. Secondary outcomes included all\u2010cause hospitalization or death. We applied propensity score balancing and Cox regression to compute adjusted hazard ratios (aHRs) in on\u2010treatment (OT) and intention\u2010to\u2010treat (ITT) analyses. Cohorts were well balanced at baseline (median age 61\u00a0years, 59% men, diabetes mellitus duration 6.6\u00a0years, 30% with preexisting cardiovascular disease). During mean follow\u2010up of 1.1\u00a0years in OT and 1.5\u00a0years in ITT analyses, empagliflozin versus liraglutide was associated with a similar rate of expanded major adverse cardiac events (OT aHR, 1.02; 95% CI, 0.91\u20131.14; ITT aHR, 1.06; 95% CI, 0.96\u20131.17), and HHF or all\u2010cause death (OT aHR, 0.97; 95% CI, 0.85\u20131.11; ITT aHR, 1.02; 95% CI, 0.91\u20131.14); and a decreased rate of a first incident HHF or loop\u2010diuretic initiation (OT aHR, 0.80; 95% CI, 0.68\u20130.94; ITT aHR, 0.87; 95% CI, 0.76\u20131.00), and of all\u2010cause hospitalization or death (OT aHR, 0.93; 95% CI, 0.89\u20130.98; ITT aHR, 0.93; 95% CI, 0.90\u20130.97).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Empagliflozin and liraglutide initiators had comparable rates of expanded major adverse cardiac events, and HHF or all\u2010cause death, whereas empagliflozin initiators had a lower rate of a first HHF or loop\u2010diuretic initiation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.019356","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T09:11:58Z","timestamp":1621933918000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Cardiovascular Events, Acute Hospitalizations, and Mortality in Patients With Type 2 Diabetes Mellitus Who Initiate Empagliflozin Versus Liraglutide: A Comparative Effectiveness Study"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9135-3474","authenticated-orcid":false,"given":"Reimar W.","family":"Thomsen","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3772-4497","authenticated-orcid":false,"given":"Jakob S.","family":"Knudsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johnny","family":"Kahlert","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisbeth M.","family":"Baggesen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Lajer","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim A\/S Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pia H.","family":"Holmgaard","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim A\/S Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ola","family":"Vedin","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim AB Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasia","family":"Ustyugova","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim International GmbH Ingelheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik T.","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-S010"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30033-5"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.07.071"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504720"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603827"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611925"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1612917"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1812389"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31149-3"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.2337\/dci19-0066"},{"key":"e_1_3_1_12_2","unstructured":"The Danish College of General Practitioners (DSAM) . 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