{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T10:09:23Z","timestamp":1760609363175,"version":"3.41.2"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,5,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Although current guidelines recommend dual antiplatelet therapy (DAPT) for 3 to 6\u00a0months following transcatheter aortic valve replacement (TAVR), there are no studies directly comparing outcomes of different durations of DAPT following TAVR.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              PubMed, EMBASE, and Cochrane Database were searched through November 2020 to identify clinical studies that investigated single antiplatelet therapy versus DAPT use following TAVR. Studies using oral anticoagulants and antiplatelet therapy concomitantly were excluded. The DAPT group was subdivided by the duration of DAPT. We extracted the risk ratios (RRs) of major or life\u2010threatening bleeding, stroke, and all\u2010cause mortality. Four randomized controlled trials, 2 propensity\u2010score matched studies, and 1 observational study were identified, yielding a total of 2498 patients who underwent TAVR assigned to the single antiplatelet therapy group (n=1249), 3\u2010month DAPT group (n=485), or 6\u2010month DAPT group (n=764). Pooled analyses demonstrated that when compared with the single antiplatelet therapy group, the rates of major or life\u2010threatening bleeding were significantly higher in the 3\u2010 and 6\u2010month DAPT groups (RR [95% CI]=2.13 [1.33\u20133.40],\n              <jats:italic>P<\/jats:italic>\n              =0.016; RR [95% CI]=2.54 [1.49\u20134.33],\n              <jats:italic>P<\/jats:italic>\n              =0.007, respectively) with no difference between the 3\u2010month DAPT versus 6\u2010month DAPT groups. The rates of stroke and all\u2010cause mortality were similar among the 3 groups.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In this network meta\u2010analysis of antiplatelet therapy following TAVR, single antiplatelet therapy with aspirin had lower bleeding without increasing stroke or death when compared with either 3\u2010 or 6\u2010month DAPT.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.019490","type":"journal-article","created":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T10:06:40Z","timestamp":1618654000000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Duration of Antiplatelet Therapy Following Transcatheter Aortic Valve Replacement: Systematic Review and Network Meta\u2010Analysis"],"prefix":"10.1161","volume":"10","author":[{"given":"Toshiki","family":"Kuno","sequence":"first","affiliation":[{"name":"Department of Medicine Icahn School of Medicine at Mount SinaiMount Sinai Beth Israel New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujiro","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Surgery St. Luke's University Health Network Bethlehem PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5740-9670","authenticated-orcid":false,"given":"Alexandros","family":"Briasoulis","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Heart Failure and Transplantation University of Iowa Iowa City IA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2367-8354","authenticated-orcid":false,"given":"Makoto","family":"Mori","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery Yale School of Medicine New Haven CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Iwagami","sequence":"additional","affiliation":[{"name":"Department of Health Services Research University of Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomo","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kawasaki Saiwai Hospital Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisato","family":"Takagi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Shizuoka Medical Center Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9485-0652","authenticated-orcid":false,"given":"Sripal","family":"Bangalore","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine New York University School of Medicine New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"doi-asserted-by":"publisher","key":"e_1_3_1_2_2","DOI":"10.1056\/NEJMoa1103510"},{"doi-asserted-by":"publisher","key":"e_1_3_1_3_2","DOI":"10.1056\/NEJMoa1514616"},{"doi-asserted-by":"publisher","key":"e_1_3_1_4_2","DOI":"10.1056\/NEJMoa1008232"},{"doi-asserted-by":"publisher","key":"e_1_3_1_5_2","DOI":"10.1056\/NEJMoa1814052"},{"doi-asserted-by":"publisher","key":"e_1_3_1_6_2","DOI":"10.1007\/s12928-017-0502-9"},{"doi-asserted-by":"publisher","key":"e_1_3_1_7_2","DOI":"10.1016\/j.amjcard.2019.05.017"},{"doi-asserted-by":"publisher","key":"e_1_3_1_8_2","DOI":"10.1007\/s12928-018-0546-5"},{"doi-asserted-by":"publisher","key":"e_1_3_1_9_2","DOI":"10.1056\/NEJMoa1911425"},{"doi-asserted-by":"publisher","key":"e_1_3_1_10_2","DOI":"10.1056\/NEJMoa2017815"},{"doi-asserted-by":"publisher","key":"e_1_3_1_11_2","DOI":"10.1093\/eurheartj\/ehx391"},{"doi-asserted-by":"publisher","key":"e_1_3_1_12_2","DOI":"10.1161\/CIR.0000000000000503"},{"doi-asserted-by":"publisher","key":"e_1_3_1_13_2","DOI":"10.1136\/bmj.l4898"},{"unstructured":"Wells G Shea B O'Connell D Peterson J Welch V Losos M Tugwell P. 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