{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:21:03Z","timestamp":1790716863170,"version":"4.1.0"},"reference-count":55,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,3,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">During the past decade, the use of transcatheter aortic valve replacement (TAVR) was extended beyond treatment\u2010na\u00efve patients and implemented for treatment of degenerated surgical bioprosthetic valves. Selection criteria for either valve\u2010in\u2010valve (viv) TAVR or redo surgical aortic valve replacement are not well established, and decision making on the operative approach still remains challenging for the interdisciplinary heart team.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">This review was intended to analyze all studies on viv\u2010TAVR focusing on short\u2010 and mid\u2010term stroke and mortality rates compared with redo surgical aortic valve replacement or native TAVR procedures. A structured literature search and review process led to 1667 potentially relevant studies on July 1, 2020. Finally, 23 studies fulfilled the inclusion criteria for qualitative analysis. All references were case series either with or without propensity score matching and registry analyses. Quantitative synthesis of data from 8509 patients revealed that viv\u2010TAVR is associated with mean 30\u2010day stroke and mortality rates of 2.2% and 4.2%, respectively. Pooled data analysis showed no significant differences in 30\u2010day stroke rate, 30\u2010day mortality, and 1\u2010year mortality between viv\u2010TAVR and comparator treatment (native TAVR [n=11\u00a0804 patients] or redo surgical aortic valve replacement [n=498 patients]).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">This review is the first one comparing the risk for stroke and mortality rates in viv\u2010TAVR procedures with native TAVR approach and contributes substantial data for the clinical routine. Moreover, this systematic review is the most comprehensive analysis on ischemic cerebrovascular events and early mortality in patients undergoing viv\u2010TAVR. In this era with increasing numbers of bioprosthetic valves used in younger patients, viv\u2010TAVR is a suitable option for the treatment of degenerated bioprostheses.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.019512","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T10:10:22Z","timestamp":1615198222000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Meta\u2010Analysis of Stroke and Mortality Rates in Patients Undergoing Valve\u2010in\u2010Valve Transcatheter Aortic Valve Replacement"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7080-6611","authenticated-orcid":false,"given":"Sascha","family":"Macherey","sequence":"first","affiliation":[{"name":"Department III of Internal Medicine University Hospital of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7746-8723","authenticated-orcid":false,"given":"Max","family":"Meertens","sequence":"additional","affiliation":[{"name":"Department III of Internal Medicine University Hospital of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Mauri","sequence":"additional","affiliation":[{"name":"Department III of Internal Medicine University Hospital of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Frerker","sequence":"additional","affiliation":[{"name":"Department III of Internal Medicine University Hospital of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Adam","sequence":"additional","affiliation":[{"name":"Department III of Internal Medicine University Hospital of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Baldus","sequence":"additional","affiliation":[{"name":"Department III of Internal Medicine University Hospital of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department III of Internal Medicine University Hospital of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000047200.36165.B8"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000503"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx391"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1814052"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1816885"},{"key":"e_1_3_1_7_2","first-page":"CD013319","article-title":"Transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis in people with low surgical risk","volume":"12","author":"Kolkailah AA","year":"2019","unstructured":"Kolkailah AA, Doukky R, Pelletier MP, Volgman AS, Kaneko T, Nabhan AF Transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis in people with low surgical risk. Cochrane Database Syst Rev. 2019;12:CD013319.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.104505"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2013.09.031"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2010.12.053"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.09.030"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivv037"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.005"},{"key":"e_1_3_1_14_2","unstructured":"Oxford University Centre for evidence\u2010based medicine \u2010 levels of evidence. http:\/\/www.cebm.net\/oxford\u2010centre\u2010evidence\u2010based\u2010medicine\u2010levels\u2010evidence\u2010march\u20102009\/. Accessed May 23 2020."},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.112.972331"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2013.06.045"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2015.03.021"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.02.057"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx455"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/joic.12498"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.7525"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.02.029"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.13976"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2010.02.061"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2010.09.049"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq406"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs533"},{"key":"e_1_3_1_29_2","first-page":"1494","article-title":"Redo aortic valve surgery versus transcatheter valve\u2010in\u2010valve implantation for failing surgical bioprosthetic valves: consecutive patients in a single\u2010center setting","volume":"7","author":"Erlebach M","year":"2015","unstructured":"Erlebach M, Wottke M, Deutsch MA, et al. Redo aortic valve surgery versus transcatheter valve\u2010in\u2010valve implantation for failing surgical bioprosthetic valves: consecutive patients in a single\u2010center setting. J Thorac Dis. 2015;7:1494\u20131500. DOI: 10.3978\/j.issn.2072\u20101439.2015.09.24.","journal-title":"J Thorac Dis"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.05.086"},{"key":"e_1_3_1_31_2","first-page":"581","article-title":"Transcatheter aortic valve\u2010in\u2010valve implantation and sutureless aortic valve replacement: two strategies for one goal in redo patients","volume":"64","author":"Santarpino G","year":"2016","unstructured":"Santarpino G, Pietsch LE, Jessl J, et al. Transcatheter aortic valve\u2010in\u2010valve implantation and sutureless aortic valve replacement: two strategies for one goal in redo patients. Minerva Cardioangiol. 2016;64:581\u2013585.","journal-title":"Minerva Cardioangiol"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivw300"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-16-00303"},{"key":"e_1_3_1_34_2","first-page":"653","article-title":"Redo procedures for degenerated stentless aortic xenografts and the role of valve\u2010in\u2010valve transcatheter techniques","volume":"51","author":"Grubitzsch H","year":"2017","unstructured":"Grubitzsch H, Zobel S, Christ T, Holinski S, Stangl K, Treskatsch S, Falk V, Laule M, et al. Redo procedures for degenerated stentless aortic xenografts and the role of valve\u2010in\u2010valve transcatheter techniques. Eur J Cardiothorac Surg. 2017;51:653\u2013659. DOI: 10.1093\/ejcts\/ezw397.","journal-title":"Eur J Cardiothorac Surg"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.04.037"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJY15M11_04"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/joic.12540"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.04.074"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2019.04.009"},{"key":"e_1_3_1_40_2","first-page":"S1875\u20102136(20)3","article-title":"Valve\u2010in\u2010valve transcatheter aortic valve implantation after failed surgically implanted aortic bioprosthesis versus native transcatheter aortic valve implantation for aortic stenosis: data from a nationwide analysis","author":"Deharo P","year":"2020","unstructured":"Deharo P, Bisson A, Herbert J, Lacour T, Saint Etienne C, Jaussaud N, Theron A, Collart F, Bourguignon T, Cuisset T, et al. Valve\u2010in\u2010valve transcatheter aortic valve implantation after failed surgically implanted aortic bioprosthesis versus native transcatheter aortic valve implantation for aortic stenosis: data from a nationwide analysis. Arch Cardiovasc Dis. 2020; S1875\u20102136(20)30108\u2010X. DOI: 10.1016\/j.acvd.2020.04.005.","journal-title":"Arch Cardiovasc Dis"},{"key":"e_1_3_1_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2018.02.054"},{"key":"e_1_3_1_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27686"},{"key":"e_1_3_1_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezx347"},{"key":"e_1_3_1_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/joic.12520"},{"key":"e_1_3_1_45_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV8I1A20"},{"key":"e_1_3_1_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.10.023"},{"key":"e_1_3_1_47_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.10302"},{"key":"e_1_3_1_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.06.037"},{"key":"e_1_3_1_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv191"},{"key":"e_1_3_1_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.06.018"},{"key":"e_1_3_1_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.03.001"},{"key":"e_1_3_1_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.01.020"},{"key":"e_1_3_1_53_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2016-309597"},{"key":"e_1_3_1_54_2","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2001.116470"},{"key":"e_1_3_1_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(03)00566-9"},{"key":"e_1_3_1_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(99)00363-2"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.120.019512","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:16:19Z","timestamp":1715598979000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.120.019512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,16]]},"references-count":55,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,3,16]]}},"alternative-id":["10.1161\/JAHA.120.019512"],"URL":"https:\/\/doi.org\/10.1161\/jaha.120.019512","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,16]]},"assertion":[{"value":"2020-10-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e019512"}}