{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T14:33:53Z","timestamp":1769265233493,"version":"3.49.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,7,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Targeting higher hemoglobin levels with erythropoietin to treat anemia in patients with chronic kidney disease is associated with increased cardiovascular risk, including that of stroke. The risks of the subtypes of stroke, ischemic, hemorrhagic, and unspecified, following the administration of erythropoietin in patients with end\u2010stage renal disease receiving hemodialysis remain unclear.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and results<\/jats:title>\n            <jats:p xml:lang=\"en\">Overall, 12\u00a0948 adult patients with end\u2010stage renal disease treated during 1999 to 2010 who had undergone hemodialysis were included. The study end points were the incidences of stroke and its subtypes. We used Cox proportional hazards regression models to estimate hazard ratios (HRs) of stroke and its subtypes in erythropoietin recipients compared with nonrecipients. Patients in the erythropoietin cohort did not have an increased risk of stroke compared with those in the nonerythropoietin cohort (adjusted HR, 1.03; 95% CI, 0.92\u20131.15). Compared with patients in the nonerythropoietin cohort, the risks of ischemic, hemorrhagic, or unspecified stroke were not higher in patients in the erythropoietin cohort (adjusted HRs, 1.08 [95% CI, 0.93\u20131.26], 0.96 [95% CI, 0.78\u20131.18], and 1.03 [95% CI, 0.80\u20131.32], respectively). Increased risks of stroke and its subtypes were not observed with even large annual defined daily doses of erythropoietin (&gt;201).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Erythropoietin in patients receiving hemodialysis is not associated with increased risk of stroke or any of its subtypes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.019529","type":"journal-article","created":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T09:00:56Z","timestamp":1624698056000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Erythropoietin Use and the Risk of Stroke in Patients on Hemodialysis: A Retrospective Cohort Study in Taiwan"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5963-6981","authenticated-orcid":false,"given":"Peir\u2010Haur","family":"Hung","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Ditmanson Medical Foundation Chia\u2010yi Christian Hospital Chiayi Taiwan"},{"name":"Department of Applied Life Science and Health Chia\u2010Nan University of Pharmacy and Science Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Ching","family":"Yeh","sequence":"additional","affiliation":[{"name":"School of Public Health College of Public Health Taipei Medical University Taipei Taiwan"},{"name":"Department of Public Health China Medical University Taichung Taiwan"},{"name":"Cancer Center Wan Fang HospitalTaipei Medical University Taipei Taiwan"},{"name":"Master Program in Applied Molecular Epidemiology College of Public Health Taipei Medical University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Yen","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ditmanson Medical Foundation Chia\u2010yi Christian Hospital Chiayi Taiwan"},{"name":"Department of Hospital and Health Care Administration Chia\u2010Nan University of Pharmacy and Science Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Hsin","family":"Muo","sequence":"additional","affiliation":[{"name":"Management Office for Health Data China Medical University Hospital Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuan\u2010Yu","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital Taipei city Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2170-9735","authenticated-orcid":false,"given":"Kuen\u2010Jer","family":"Tsai","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine College of Medicine National Cheng Kung University Tainan Taiwan"},{"name":"Center of Clinical Medicine National Cheng Kung University HospitalCollege of MedicineNational Cheng Kung University Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-111-12-992"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198907203210305"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90733-L"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1990.03440060071035"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1991.20"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.19.10526"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.267"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq344"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2004.03.004"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1687"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.10.035"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907845"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13167-010-0056-8"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.2014.1332"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.79"},{"key":"e_1_3_1_17_2","unstructured":"World Health Organization. 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