{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T20:28:04Z","timestamp":1782505684131,"version":"3.54.5"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,4,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">In patients undergoing transcatheter aortic valve replacement (TAVR), those with small left ventricle (LV) may have an increased risk of poor outcomes, because small LV is associated with low\u2010flow (LF), left ventricular hypertrophy. However, the impact of small LV on patients undergoing TAVR remains unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We examined 2584 patients who underwent TAVR between October 2013 and May 2017 using data from the Japanese multicenter registry. On the basis of the American Society of Echocardiography guidelines, small LV was defined as left ventricular end\u2010diastolic dimension &lt;42.0\u00a0mm for men or &lt;37.8\u00a0mm for women. The 2\u2010year clinical outcomes were compared between patients with and without small LV using multivariable Cox regression analyses and propensity score matching. Subgroup analyses by LF, left ventricular hypertrophy were performed. Of 2584 patients who underwent TAVR, 466 (18.0%) had small LV. Patients with small LV had smaller body size and less comorbidity, and were more likely to have LF status compared with those without. Small LV was associated with a higher 2\u2010year all\u2010cause (20.8% versus 14.3%; adjusted hazard ratio [HR],1.58 [95% CI, 1.20\u20132.09];\n              <jats:italic>P<\/jats:italic>\n              =0.0013) and cardiovascular mortality (8.8% versus 5.5%; adjusted HR, 1.93 [95% CI, 1.25\u20132.98];\n              <jats:italic>P<\/jats:italic>\n              =0.0028). Propensity score matching analysis showed consistent findings. In subgroup analyses, LF, left ventricular hypertrophy did not interact with small LV.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Small LV, determined by a simple echocardiographic parameter, was associated with poorer clinical outcomes after TAVR regardless of LF, left ventricular hypertrophy. LV size may be useful for assessing clinical outcomes after TAVR.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.umin.ac.jp\/ctr\/index.htm\">https:\/\/www.umin.ac.jp\/ctr\/index.htm<\/jats:ext-link>\n              ; Unique identifier: UMIN000020423.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.019543","type":"journal-article","created":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T10:23:44Z","timestamp":1616235824000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Small Left Ventricle and Clinical Outcomes After Transcatheter Aortic Valve Replacement"],"prefix":"10.1161","volume":"10","author":[{"given":"Tetsuya","family":"Saito","sequence":"first","affiliation":[{"name":"Department of Cardiology Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7889-2083","authenticated-orcid":false,"given":"Taku","family":"Inohara","sequence":"additional","affiliation":[{"name":"Department of Cardiology Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Yoshijima","sequence":"additional","affiliation":[{"name":"Department of Cardiology Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7755-5771","authenticated-orcid":false,"given":"Fumiaki","family":"Yashima","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saiseikai Utsunomiya Hospital Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3002-966X","authenticated-orcid":false,"given":"Hikaru","family":"Tsuruta","sequence":"additional","affiliation":[{"name":"Department of Cardiology Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Cardiology Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Naganuma","sequence":"additional","affiliation":[{"name":"Department of Cardiology New Tokyo Hospital Matsudo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7206-4538","authenticated-orcid":false,"given":"Kazuki","family":"Mizutani","sequence":"additional","affiliation":[{"name":"Department of Cardiology Osaka City General Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Yamawaki","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saiseikai Yokohama\u2010City Eastern Hospital Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Tada","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sendai Kousei Hospital Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7948-9915","authenticated-orcid":false,"given":"Futoshi","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shonan Kamakura General Hospital Kamakura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Shirai","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kokura Memorial Hospital Kokura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Tabata","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Tokyo Bay Urayasu\u2010Ichikawa Medical Center Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ueno","sequence":"additional","affiliation":[{"name":"Department of Cardiology Toyama University Hospital Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Takagi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ogaki Municipal Hospital Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Cardiology Teikyo University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology Toyohashi Heart Center Toyohashi Japan"},{"name":"Department of Cardiology Nagoya Heart Center Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1750-1982","authenticated-orcid":false,"given":"Kentaro","family":"Hayashida","sequence":"additional","affiliation":[{"name":"Department of Cardiology Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1202277"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1514616"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1400590"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1700456"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1814052"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1816885"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001193"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)90883-E"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.955039"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00630-0"},{"key":"e_1_3_2_12_2","first-page":"430","article-title":"Pathophysiological factors associated with left ventricular perforation in transcatheter aortic valve implantation by transfemoral approach","volume":"26","author":"Owais T","year":"2017","unstructured":"Owais T, El Garhy M, Fuchs J, Disha K, Elkaffas S, Breuer M, Lauer B, Kuntze T. Pathophysiological factors associated with left ventricular perforation in transcatheter aortic valve implantation by transfemoral approach. J Heart Valve Dis. 2017;26:430\u2013436.","journal-title":"J Heart Valve Dis"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2016.12.028"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.03.011"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2020-001269"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV8I7A121"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.02.009"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2009.07.013"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.06.019"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27547"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.025630"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0196031"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.01.240"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40119-019-0134-5"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2019.11.013"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.11.013"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.02.005"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.76.3.250"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.02.011"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.03.042"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz892"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz550"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.120.019543","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:17:44Z","timestamp":1715599064000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.120.019543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,6]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,4,6]]}},"alternative-id":["10.1161\/JAHA.120.019543"],"URL":"https:\/\/doi.org\/10.1161\/jaha.120.019543","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,6]]},"assertion":[{"value":"2020-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e019543"}}